1073117-27-7

Basic information

• Product Name: 2-[(N-tert-butoxycarbonyl)-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]amino]-3-nitrobenzoic acid
• Synonyms: 2-[(N-tert-butoxycarbonyl)-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]amino]-3-nitrobenzoic acid
• CAS NO: 1073117-27-7
• Molecular Weight: 758.833
• Mol File: 1073117-27-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[(N-tert-butoxycarbonyl)-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]amino]-3-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(N-tert-butoxycarbonyl)-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]amino]-3-nitrobenzoic acid(1073117-27-7)
• EPA Substance Registry System: 2-[(N-tert-butoxycarbonyl)-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]amino]-3-nitrobenzoic acid(1073117-27-7)

Safety Data

• Hazardous Substances Data: 1073117-27-7(Hazardous Substances Data)

Upstream product

• 136285-65-9 ethyl 2-[(N-tert-butoxycarbonyl)amino]-3-nitrobenzoate 
• 124750-51-2 N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole 
• 906474-56-4 ethyl 2-[(N-tert-butoxycarbonyl)-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]amino]-3-nitrobenzoate 

Downstream Products

• 1073117-28-8 (+/-)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-[(N-tert-butoxycarbonyl)-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]amino]-3-nitrobenzoate 
• 145040-37-5 candesartan cilexetil 

Relevant articles and documents

A NEW PROCESS FOR THE PREPARATION OF CANDESARTAN CILEXETIL

The present invention discloses the process for the preparation of candesartan cilexetil comprising the steps of hydrogenation of N02group of 1-(((cyclohexyloxy)carbonyl)oxy)ethyl 2-((tert-butoxycarbonyl)((2'-(1-tntyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-nitrobenzoate by using a catalyst in an organic solvent, subsequent cleavage of the N-Boc group under acidic condition, followed by isolation of solid 1-(((cyclohexyloxy)carbonyl) oxy)ethyl 2-(((2'-(l H-tetrazol-5-yl)-[1,1'-bipheny|]-4-yl)methyl)amino)-3-aminobenzoate in the form of any pharmaceutically acceptable salt and ring closure by using tetraethyl orthocarbonate in an organic solvent to obtain the final product candesartan cilexetil.