107316-88-1

Basic information

• Product Name: demethylzeylasteral
• Synonyms: demethylzeylasteral;(9beta,13alpha,14beta,20alpha)-2,3-Dihydroxy-9,13-dimethyl-6,23-dioxo-24,25,26-trinoroleana-1,3,5(10),7-tetraen-29-oic acid;A-Friedo-24-noroleana-1,3,5(10),7-tetraen-29-oicacid
• CAS NO: 107316-88-1
• Molecular Formula: C29H36O6
• Molecular Weight: 480.59254
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 107316-88-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 663.6±55.0 °C(Predicted)
• Appearance: /
• Density: 1.31
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 4.78±0.70(Predicted)
• CAS DataBase Reference: demethylzeylasteral(CAS DataBase Reference)
• NIST Chemistry Reference: demethylzeylasteral(107316-88-1)
• EPA Substance Registry System: demethylzeylasteral(107316-88-1)

Safety Data

• Hazardous Substances Data: 107316-88-1(Hazardous Substances Data)

Usage

Description

Demethylzeylasteral is a carbopolycyclic compound with the chemical formula C29H36O6, originally isolated from Tripterygium wilfordii. It is a natural product known for its inhibitory properties and potential applications in various fields.

Uses

Used in Pharmaceutical Applications:
Demethylzeylasteral is used as an inhibitor to block the Bcl-XL-Bid interaction, which plays a crucial role in regulating cell death and survival. This interaction inhibition can be beneficial in the development of treatments for various diseases and conditions.
Used in Immunosuppressive Applications:
Demethylzeylasteral is also used as an immunosuppressive monomer, which can help regulate the immune system and potentially be used in the treatment of autoimmune diseases and conditions requiring immunosuppression.
Used in Drug Metabolism Inhibition:
Demethylzeylasteral exhibits inhibition towards the glucuronidation elimination reaction of SN-38, a metabolite of the chemotherapy drug irinotecan. This property can be utilized to improve the efficacy and pharmacokinetics of certain chemotherapeutic agents.

Related news

Effects of demethylzeylasteral (cas 107316-88-1) and celastrol on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction08/13/2019

The male antifertility effect of a water–chloroform extract of Tripterygium wilfordii Hook. f. (GTW) and several monomers isolated from GTW has attracted worldwide interest. In the present study, the effects of two isolated monomers from GTW, demethylzeylasteral and celastrol, on the Ca2+ chann...detailed

Immunosuppressive effects of demethylzeylasteral (cas 107316-88-1) in a rat kidney transplantation model08/12/2019

In this study, we examined the immunosuppressive activity of demethylzeylasteral (T-96), isolated from the traditional Chinese herbal medicine, Tripterygium wilfordii Hook f. Its immunosuppressive effect was investigated using mouse splenocytes in vitro, and in an in vivo rat kidney transplant m...detailed