1073543-01-7Relevant articles and documents
Importance of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase tyrosine 707 residue for chair-boat bicyclic ring formation and deprotonation reactions
Wu, Tung-Kung,Wang, Tsai-Ting,Chang, Cheng-Hsiang,Liu, Yuan-Ting,Shie, Wen-Shiang
, p. 4959 - 4962 (2008)
(Chemical Equation Presented) A contact mapping strategy was applied to identify putative amino acid residues that influence the oxidosqualene- lanosterol B-ring cyclization reaction. A bicyclic intermediate with two altered deprotonation products, in conjunction with lanosterol, were isolated from the ERG7Y707X mutants, indicating that the Tyr707 residue may play a functional role in stabilizing the chair-boat bicyclic C-8 cation and the lanosteryl C-8/C-9 cation intermediates.