107433-65-8Relevant articles and documents
PHENYLENE, FURYL, AND THIENYL LEUKOTRIENE B4 ANALOGUES
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, (2008/06/13)
This invention relates to leukotriene B 4 antagonists having the structure STR1 and the pharmaceutically acceptable addition salts thereof; wherein R 1 is lower alkyl having 1-10 carbon atoms; or lower alkenyl or alkynyl having 2-10 carbon atoms; or lower
AN IMPROVED PROCEDURE FOR THE GENERATION AND SELECTIVE TRAPPING OF 2,4'-DILITHIOPHENYLETHYNE
Furber, Mark,Taylor, Richard J. K.,Burford, S. Cliff
, p. C35 - C38 (2007/10/02)
2,4'-Dilithiophenylethyne, prepared by treatment of 4-bromophenylethyne with two equivalents of butyllithium, reacts selectively with electrophilic reagents at the 4'-position provided the correct temperature and solvent combination are employed.The successive addition of two different electrophiles gives the 2,4'-dialkylated product in a regioselective manner.