1075623-35-6

Basic information

• Product Name: (2E,2'E)-N,N'-(thiodiethane-2,1-diyl)bis[3-(3,4-dichlorophenyl)acrylamide] hydrochloride
• Synonyms: (2E,2'E)-N,N'-(thiodiethane-2,1-diyl)bis[3-(3,4-dichlorophenyl)acrylamide] hydrochloride
• CAS NO: 1075623-35-6
• Molecular Weight: 518.291
• Mol File: 1075623-35-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2E,2'E)-N,N'-(thiodiethane-2,1-diyl)bis[3-(3,4-dichlorophenyl)acrylamide] hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2E,2'E)-N,N'-(thiodiethane-2,1-diyl)bis[3-(3,4-dichlorophenyl)acrylamide] hydrochloride(1075623-35-6)
• EPA Substance Registry System: (2E,2'E)-N,N'-(thiodiethane-2,1-diyl)bis[3-(3,4-dichlorophenyl)acrylamide] hydrochloride(1075623-35-6)

Safety Data

• Hazardous Substances Data: 1075623-35-6(Hazardous Substances Data)

Upstream product

• 871-76-1 2,2-diaminoethylthioether 
• 7312-27-8 3,4-Dichlorocinnamic acid 

Downstream Products

• 1075623-37-8 (2E,2'E)-N,N'-(sulfinyldiethane-2,1-diyl)bis[3-(3,4-dichlorophenyl)acrylamide] hydrochloride 
• 1075623-39-0 (2E,2'E)-N,N'-(sulfonyldiethane-2,1-diyl)bis[3-(3,4-dichlorophenyl)acrylamide] hydrochloride 

Relevant articles and documents

Synthesis and pharmacological evaluation of bis-3-(3,4-dichlorophenyl)acrylamide derivatives as glycogen phosphorylase inhibitors

During our research using a high-throughput screening system for discovery of a new class of human liver glycogen phosphorylase a (hLGPa) inhibitors, a series of 3-(3,4-dichlorophenyl)acrylamide derivatives were synthesized, and their inhibitory activities toward hLGPa were evaluated. Among the derivatives, (2E,2′E)-N,N′-pentane-1,5-diylbis[3-(3,4-dichlorophenyl)acrylamide] (6c) inhibited hLGPa with an IC50 value of 0.023 μM. An X-ray crystallographic study of the enzyme-6c complex showed that the inhibitor is bound at the dimer interface site, where the 3,4-dichlorophenyl moiety interacts hydrophobically with the enzyme.