1075687-41-0Relevant articles and documents
Enantioselective catalytic epoxidation of α,β-enones promoted by fluorous α,α-diaryl-l-prolinols
Cui, Haifeng,Li, Yawen,Zheng, Changwu,Zhao, Gang,Zhu, Shizheng
, p. 45 - 50 (2008)
Enantioselective (up to 87% ee) epoxidation of a variety of α,β-enones to form α,β-epoxy ketones is described using a series of fluorous α,α-diaryl-l-prolinols as bifuncational organocatalysts and tert-butyl hydrogenperoxide (TBHP) as an oxidant.
A highly enantioselective phase-transfer catalyzed epoxidation of enones with a mild oxidant, trichloroisocyanuric acid
Ye, Jinxing,Wang, Yongcan,Liu, Renhua,Zhang, Guofu,Zhang, Qing,Chen, Jiping,Liang, Xinmiao
, p. 2714 - 2715 (2003)
The enantioselective epoxidation can be carried out using trichloroisocyanuric acid (TCCA) as oxidant in the presence of chiral quaternary ammonium salt as a phase-transfer catalyst; treatment of chalcone derivatives with TCCA under mild conditions afford
4-Substituted-α,α-diaryl-prolinols improve the enantioselective catalytic epoxidation of α,β-enones
Li, Yawen,Liu, Xinyuan,Yang, Yingquan,Zhao, Gang
, p. 288 - 291 (2007/10/03)
To seek novel metal-free organic catalysts for epoxidation with high stereoselectivity, a series of 4-substituted-α,α-diaryl-prolinols were synthesized in four steps from trans-4-hydroxyl-L-proline. These prolinol derivatives catalyzed the asymmetric epoxidation of α,β-enones to give the corresponding chiral epoxides in good yields and high enantioselectivities under mild reaction conditions. Studies of substituent effects on enantioselectivity revealed that steric bulk and electronic effect promoted higher enantioselectivity, and prolinol 8a was found to be the best catalyst until now.
