1076-47-7

Basic information

• Product Name: 2,3,4-TRIMETHYLBENZOICACID
• Synonyms: 2,3,4-TRIMETHYLBENZOICACID
• CAS NO: 1076-47-7
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.20108
• Mol File: 1076-47-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 105.65°C (estimate)
• Boiling Point: 288.61°C (estimate)
• Flash Point: 143.5°C
• Appearance: /
• Density: 1.0670 (estimate)
• Vapor Pressure: 0.000256mmHg at 25°C
• Refractive Index: 1.5198 (estimate)
• CAS DataBase Reference: 2,3,4-TRIMETHYLBENZOICACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4-TRIMETHYLBENZOICACID(1076-47-7)
• EPA Substance Registry System: 2,3,4-TRIMETHYLBENZOICACID(1076-47-7)

Safety Data

• Hazardous Substances Data: 1076-47-7(Hazardous Substances Data)

Usage

Description

2,3,4-Trimethylbenzoic acid, a derivative of benzoic acid, is a chemical compound characterized by its molecular formula C10H12O2. It features a benzene ring with three methyl groups attached at the 2nd, 3rd, and 4th positions, resulting in a white crystalline powder. 2,3,4-TRIMETHYLBENZOICACID is insoluble in water but readily soluble in organic solvents. Its unique structure and properties make it a versatile compound in various applications, particularly in the pharmaceutical, fragrance, and flavoring industries.

Uses

Used in Pharmaceutical Industry:
2,3,4-Trimethylbenzoic acid is used as an intermediate in the synthesis of various pharmaceuticals. Its chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Fragrance Industry:
2,3,4-Trimethylbenzoic acid is used as a raw material in the production of various fragrances. Its unique aroma profile contributes to the creation of distinct and appealing scents for perfumes, cosmetics, and other scented products.
Used in Flavoring Industry:
In the flavoring industry, 2,3,4-Trimethylbenzoic acid is utilized to enhance the taste and aroma of food and beverage products. Its ability to impart a specific flavor profile makes it a valuable ingredient in the development of new and innovative flavors.
Used in Medicinal Chemistry Research:
2,3,4-Trimethylbenzoic acid is studied for its potential anti-inflammatory and antimicrobial properties. Its ability to modulate biological processes and exhibit therapeutic effects makes it a promising candidate for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C10H12O2/c1-6-4-5-9(10(11)12)8(3)7(6)2/h4-5H,1-3H3,(H,11,12)

Upstream product

• 488-23-3 1,2,3,4-Tetramethylbenzene 
• 854180-50-0 2,3,4-trimethyl-benzyl alcohol 
• 526-73-8 1,2,3-trimethylbenzene 
• 75-36-5 acetyl chloride 
• 1082-77-5 3-(2,3,4-Trimethylbenzoyl)propionsaeure 
• 509-14-8 tetranitromethane 
• 7697-37-2 nitric acid 
• 1086-70-0 3-(2.3,4-Trimethyl-benzoyl)-propionsaeure-aethylester 
• 60368-02-7 Methyl-2,3,4-trimethylbenzylether 
• 60392-10-1 2,3,4-Trimethylbenzylacetat 
• 60367-94-4 2.3.4-Trimethylbenzylnitrat 
• 124-38-9 carbon dioxide 

Downstream Products

• 112277-80-2 azidocarbonyl-4 hemimellitene 
• 1416990-27-6 C₁₄H₂₁NO 
• 90918-98-2 2,3,4-trimethyl-benzoyl chloride 
• 1416990-28-7 C₁₄H₂₀BrNO 
• 13667-30-6 2,3,4-trimethyl-5-nitrobenzoic acid 
• 112277-84-6 amino-4 bromo-5 hemimellitene 
• 112277-74-4 Trimethyl-(3,4,5-trimethyl-phenyl)-silane 
• 1467-35-2 2,3,4-trimethylaniline 
• 32591-43-8 5-bromo-1,2,3-trimethylbenzene 
• 190367-55-6 5-Methanesulfonyl-2,3,4-trimethyl-benzoic acid methyl ester 

Relevant articles and documents

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Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

A series of analogs of the immunomodulary drugs lenalidomide (1) and pomalidomide (2), in which the amino group is replaced with various isosteres, was prepared and assayed for immunomodulatory activity and activity against cancer cell lines. The 4-methyl and 4-chloro analogs 4 and 15, respectively, displayed potent inhibition of tumor necrosis factor-α (TNF-α) in LPS-stimulated hPBMC, potent stimulation of IL-2 in a human T cell co-stimulation assay, and anti-proliferative activity against the Namalwa lymphoma cell line. Both of these analogs displayed oral bioavailability in rat.

Hydrocarbures arylaliphatiques. Partie VIII. Etude cinetique de la protodesilylation de benzocyclenes tricycliques

A kinetic study of the protodesilylation of silylated derivatives of hemimellitene, 2a,3,4,5 tetrahydro acenaphthene and 1H 2,2a,3,4,5,6 hexahydro benzo(c,d)azulene is described.These results complete those published previously and which are related to the influence of the ring size of alicyclic systems pericondensed to a benzene nucleus on the reactivity of the nucleus to acetylation or bromination.The silylated derivatives were prepared from the corresponding bromo compounds.The synthesis of the bromo compounds, some of which were described in an earlier study, is completed here by using a synthetic pathway which allows the preparation of the β isomers starting from the ortho bromo derivatives.The kinetic results show a deactivation of the β position of the hemimellitene.A little deactivation of ortho α position of the five membered ring in the tricyclic compounds is also observed.This last result, significant in the case of bromination, seems to be related to the Mills-Nixon effect and can be explained by using Streitwieser's hybridization for the ? skeleton.