107624-70-4

Basic information

• Product Name: Phenol, 2-chloro-4-[(4-methylphenyl)sulfonyl]-
• CAS NO: 107624-70-4
• Molecular Formula: C13H11ClO3S
• Molecular Weight: 282.748
• Mol File: 107624-70-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Phenol, 2-chloro-4-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2-chloro-4-[(4-methylphenyl)sulfonyl]-(107624-70-4)
• EPA Substance Registry System: Phenol, 2-chloro-4-[(4-methylphenyl)sulfonyl]-(107624-70-4)

Safety Data

• Hazardous Substances Data: 107624-70-4(Hazardous Substances Data)

Upstream product

• 107776-77-2 2-chloro-1-methoxy-4-(toluene-4-sulfonyl)-benzene 
• 109966-23-6 2-chloro-1-methoxy-4-p-tolylsulfanyl-benzene 
• 624-31-7 4-tolyl iodide 
• 98-59-9 p-toluenesulfonyl chloride 
• 95-57-8 2-monochlorophenol 
• 104-15-4 toluene-4-sulfonic acid 
• 599-76-8 2-chlorophenyl 4-methylbenzenesulfonate 
• 143538-80-1 1,2-dichloro-4-tosylbenzene 

Relevant articles and documents

Graphite/methanesulfonic acid (GMA) as a new reagent for sulfonylation of phenols and thia-Fries rearrangement of aryl sulfonates to sulfonylphenols

A new facile method for direct sulfonylation of phenols was developed. Graphite in methanesulfonic acid (GMA) was used to prepare sulfonylphenols by sulfonylation of phenol and naphthalene derivatives with p-toluenesulfonic acid (=4-methylbenzenesulfonic acid) (Table 1) and the thia-Fries rearrangement of aryl sulfonates (Table 4). Mechanistic studies showed that the sulfonylation reaction of phenols in GMA occurred through an initial sulfonate formation followed by a thia-Fries rearrangement of the aryl sulfonate by an intermolecular mechanism (Scheme 3).

A convenient synthesis of 2-nitrophenols from 1,2-dichlorobenzenes

Aromatic nucleophilic substitution of 1,2-dichlorobenzenes 1 possessing a strong electron-withdrawing group in the 4-position with a nitrite ion give the corresponding 2-nitrophenols 5.