107668-79-1 Usage
Description
Bulleyaconitine A is an aconitine-type diterpene alkaloid with the molecular formula C35H49NO10. It was first isolated and extracted in 1980 from a traditional analgesic and anti-inflammatory herb known as dianxi dula or dianxi wutou (Aconitum bulleyanum Diels), which is native to the western region of Yunnan. The compound can also be separated from other Aconitum plants, such as cujing wutou (Aconitum crassicaule W.T. Wang), changhui wutou (Aconitum georgei Comber), and zhiyuan wutou (Aconitum transsectum Diels). Bulleyaconitine A appears as a white powder and is soluble in methanol, ethanol, chloroform, and ether. It is insoluble in water but can be easily dissolved in dilute hydrochloric acid or dilute sulfuric acid, with a melting point of 160-165°C.
Uses
1. Used in Pharmaceutical Industry:
Bulleyaconitine A is used as an active pharmaceutical ingredient for its analgesic and anti-inflammatory properties. It is derived from traditional herbs and has potential applications in the development of new drugs targeting pain and inflammation.
2. Used in Research and Development:
Bulleyaconitine A serves as a valuable compound for scientific research, particularly in the fields of pharmacology, biochemistry, and natural product chemistry. Its unique structure and properties make it an interesting subject for studying the mechanisms of action, potential drug interactions, and the development of novel therapeutic agents.
3. Used in Traditional Medicine:
Bulleyaconitine A is used in traditional medicine, particularly in the preparation of herbal remedies for pain relief and inflammation reduction. Its long history of use and well-documented efficacy contribute to its continued importance in traditional healing practices.
4. Used in Toxicological Studies:
Due to its potent biological activities, Bulleyaconitine A is also used in toxicological research to understand the mechanisms of its toxicity and to develop strategies for safe use and potential detoxification methods.
5. Used in Drug Delivery Systems:
Similar to gallotannin, Bulleyaconitine A can be explored for its potential applications in drug delivery systems. Researchers can investigate the use of various organic and metallic nanoparticles as carriers for Bulleyaconitine A delivery, aiming to improve its bioavailability, delivery, and therapeutic outcomes.
History
In 1983, it was confirmed that bulleyaconitine A shows obvious analgesic and antiinflammatory effects by preclinical pharmacological tests . Clinical trials were
carried out in 29 hospitals in 9 provinces in 1984. Bulleyaconitine A passed technical appraisals in May 1985 and was first formally put into production by Yunnan
Honghe Pingbian pharmaceutical company, where it obtained the trade name
“Bulleyaconitine A.” Bulleyaconitine A has been listed into the Pharmacopoeia of
the People’s Republic of China (2015). In recent years, bulleyaconitine A has shown
a great market growth and competitive power, owing to its exact curative effect and
rapid clinical promotion in chronic disease and rheumatic immune disease.
Pharmacology
1. Anti-inflammatory and analgesic effect. Bulleyaconitine A plays a significant
anti-inflammatory effect by inhibiting the release of prostaglandins. The analgesic effect may be related to the rivalry of 5-HT and the inhibition of inflammatory
chemokines in the brain, because inhibition of PGE2 release may lead to disinhibition of β-endorphin . Further studies showed that bulleyaconitine A achieved
the analgesic effect by effectively reducing sodium ion current, the electrophysiological basis on which pain conduction is dependent . Zhanguo Niu et?al.
found that bulleyaconitine A could be used to treat mild and moderate burn pain,
with less adverse reactions and no addiction . Thus, bulleyaconitine A may be
suitable for long-term use as a choice of analgesic therapy for burn pain. Recently,
through clinical observation on the effect of bulleyaconitine A treatment in acute
gouty arthritis, some scholars discovered that bulleyaconitine A brought about
good effect and could effectively improve the clinical symptoms of patients by
taking 0.4?mg bulleyaconitine A orally three times in daily .2. Immune regulation. Bulleyaconitine A has obvious inhibitory effects to immune
cells involved in joint inflammation, which may have a close relationship to its
clinical anti-inflammatory effect. Ye Lu et?al. studied the influence of bulleyaconitine A on partial immune functions of BALB/c mice and found that 0.32?mg/kg
bulleyaconitine A inhibits some immune functions of BALB/c mice . Moreover,
it was reported that bulleyaconitine A significantly inhibited the phagocytic function and the ability to secrete nitric oxide (NO) of macrophages .3. Other pharmacological effects. An injection of 0.1 mg/kg bulleyaconitin A in
fasting rat can inhibit the formation of corneal neovascularization induced by
alkali burn . Bulleyaconitine A also has local anesthesia and antipyretic effect.
Besides, bulleyaconitine A can be used for the treatment of lumbar muscle strain,
scapulohumeral periarthritis, and sprain of limbs.
Clinical Use
1. Rheumatic immune disease. Since listing, bulleyaconitine A has been applied in
clinical treatment for rheumatoid arthritis and osteoarthritis, receiving good
curative effects.2. Chronic pain. Bulleyaconitine A does not belong to NSAID, and it exerts its
effects by regulating the sodium ion channel. So there is little psychological
dependence and organ toxicity, avoiding gastrointestinal/cardiovascular/renal
adverse reactions and drug dependence or other potential dangers caused by
NSAID and opioid analgesics.
Check Digit Verification of cas no
The CAS Registry Mumber 107668-79-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,6,6 and 8 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 107668-79:
(8*1)+(7*0)+(6*7)+(5*6)+(4*6)+(3*8)+(2*7)+(1*9)=151
151 % 10 = 1
So 107668-79-1 is a valid CAS Registry Number.
InChI:InChI=1/C35H49NO9/c1-8-36-17-32(18-40-3)14-13-23(42-5)35-22-15-33(39)24(43-6)16-34(45-19(2)37,27(31(35)36)29(44-7)30(32)35)25(22)26(33)28(38)20-9-11-21(41-4)12-10-20/h9-12,22-27,29-31,39H,8,13-18H2,1-7H3
