107703-93-5

Basic information

• Product Name: (4-isopropylphenyl)(piperidin-4-yl)methanone
• Synonyms: (4-isopropylphenyl)(piperidin-4-yl)methanone
• CAS NO: 107703-93-5
• Molecular Weight: 231.338
• Mol File: 107703-93-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (4-isopropylphenyl)(piperidin-4-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-isopropylphenyl)(piperidin-4-yl)methanone(107703-93-5)
• EPA Substance Registry System: (4-isopropylphenyl)(piperidin-4-yl)methanone(107703-93-5)

Safety Data

• Hazardous Substances Data: 107703-93-5(Hazardous Substances Data)

Upstream product

• 59084-16-1 1-acetylpiperidine-4-carbonyl chloride 
• 25503-90-6 1-acetyl-piperidine-4-carboxylic acid 
• 1267998-61-7 1-(4-(4-isopropylbenzoyl)piperidin-1-yl)ethanone 

Downstream Products

• 216989-64-9 1-benzyl-4-(4-isopropylbenzoyl)piperidine 

Relevant articles and documents

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

Monoacylglycerol lipase (MAGL) is the enzyme degrading the endocannabinoid 2-arachidonoylglycerol, and it is involved in several physiological and pathological processes. The therapeutic potential of MAGL is linked to several diseases, including cancer. The development of MAGL inhibitors has been greatly limited by the side effects associated with the prolonged MAGL inactivation. Importantly, it could be preferable to use reversible MAGL inhibitors in vivo, but nowadays only few reversible compounds have been developed. In the present study, structural optimization of a previously developed class of MAGL inhibitors led to the identification of compound 23, which proved to be a very potent reversible MAGL inhibitor (IC50 = 80 nM), selective for MAGL over the other main components of the endocannabinoid system, endowed of a promising antiproliferative activity in a series of cancer cell lines and able to block MAGL both in cell-based as well as in vivo assays.

PROMOTERS FOR THE PROLIFERATION AND DIFFERENTIATION OF STEM CELLS AND/OR NEURON PRECURSOR CELLS

An agent for promoting the proliferation or differentiation of a stem cell and/or neural progenitor cell, comprising a compound represented by Formula: wherein each of R1 and R2 is H, a hydrocarbon group or a heterocyclic group, or taken together with the adjacent carbon atom to form a ring, R3 is H, a hydrocarbon group or a heterocyclic group, W is a group represented by Formula: wherein Ring A is an optionally substituted benzene ring, Ring B is an optionally substituted 5- to 7-membered nitrogen-containing heterocyclic ring, R4 is an acyl group having an aliphatic hydrocarbon group, which is substituted by an aromatic group and may have a further substitutent, or aromatic group, R5 is H, C1-6 alkyl or acyl, R4c is an aromatic group, an aliphatic hydrocarbon group or acyl, and X is O or S; Y is O, S or NH, Ring C is an optionally substituted benzene ring, or a salt or prodrug thereof is provided.