107734-26-9Relevant articles and documents
A Catalytic Construction of Indoles via Formation of Ruthenium Vinylidene Species from N-Arylynamides
Tayu, Masanori,Watanabe, Ryuta,Isogi, Satoshi,Saito, Nozomi
, p. 1147 - 1151 (2021/01/04)
Treatment of ynamides with a catalytic amount of TpRuCl(PPh3)2 resulted in the construction of indole scaffolds known as privileged structure motifs. This reaction involved a cascade of 1,2-rearrangement and cyclization carrying out C?C bond formation via a ruthenium vinylidene intermediate, as revealed by a deuterium-labeling experiments. Furthermore, the transformation of multi-functionalized ynamide, derived from a practical drug molecule, showed a high functional group tolerance of this reaction. (Figure presented.).
Method for removing sulfinyl group in heteroaryl compound
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Paragraph 0045-0048, (2019/10/01)
The invention discloses a method for removing a sulfinyl group in a heteroaryl compound. The method is characterized in that a heteroaryl cyclic sulfoxide compound represented by formula (Ia) or formula (Ib) and trimethylsilylphenyl trifluoromethanesulfonate represented by formula (II) used a substrate are reacted in the presence of cesium fluoride to obtain a sulfinyl group-removed heteroaryl compound represented by formula (IIIa) or (IIIb). The method can rapidly remove the sulfinyl group in the heteroaryl cyclic sulfoxide compound, does not need a metal catalyst with poor safety or highly toxic organic reagents, and is safe. The method has the advantages of mild conditions, strong compatibility with some sensitive benzenesulfonyl groups and Boc groups, simplicity in post-treatment, andsuitableness for industrial production.
Development of isomerization and cycloisomerization with use of a ruthenium hydride with N-heterocyclic carbene and its application to the synthesis of heterocycles
Arisawa, Mitsuhiro,Terada, Yukiyoshi,Takahashi, Kazuyuki,Nakagawa, Masako,Nishida, Atsushi
, p. 4255 - 4261 (2007/10/03)
A pure ruthenium hydride complex with N-heterocyclic carbene (NHC) ligand was efficiently generated from the reaction of a second-generation Grubbs ruthenium catalyst with vinyloxytrimethylsilane and unambiguously characterized. This ruthenium hydride complex showed high catalytic activity for the selective isomerization of terminal olefin and for the cycloisomerization of 1,6-dienes. These reactions of N-allyl-o-vinylaniline lead to novel synthetic methods for heterocycles such as indoles and 3-methylene-2,3-dihydroindoles, which are useful synthons for bioactive natural products. These procedures address an important issue in diversity-oriented synthesis.