107749-65-5Relevant articles and documents
ESTERS α-METHYLENIQUES ET α-HYDROXYMETHYLES PAR ADDITION D'ORGANOLITHIENS OU MAGNESIENS SUR L' α-(HYDROXYMETHYL) ACRYLATE D'ETHYLE ET SES DERIVES EN PRESENCE DE CUIVRE(I)
Amri, Hassen,Rambaud, Monique,Villieras, Jean
, p. C27 - C32 (1986)
α-(Methylene)- and α-(hydroxymethyl)-alkanoic esters are prepared by substitution of α-(acetoxymethyl) acrylate by Grignard reagents in the presence of a catalytic amount of copper(I) salt, or by addition of an excess (2.5 equivalents) of dialkylcopper ma
PROCESS FOR PRODUCING OPTICALLY ACTIVE 3-HYDROXYPROPIONIC ESTER DERIVATIVE
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Page/Page column 14, (2010/02/13)
The present invention is to provide a process for simply producing an optically active 3-hydroxypropionic ester derivative useful as a medicament intermediate from an inexpensive material. More specifically, the present invention is directed to a process for producing an optically active 3-hydroxypropionic ester derivative comprising reacting an acetic ester derivative available at low cost with a base and a formic ester, thereby converting the acetic ester derivative into a 2-formylacetic ester derivative, and thereafter, stereospecifically reducing the formyl group of the derivative by use of an enzymatic source capable of stereoselectively reducing the formyl group of the derivative.