107754-15-4 Usage
Description
Methyl-Benzoate,Zafirlukast, is a chemical compound that serves as an intermediate in the synthesis of Methyl 4-[(5-Amino-1-methylindol-3-yl)methyl]-3-methoxybenzoate (M258650), which is further utilized in the preparation of Zafirlukast (Z125000). Zafirlukast is a potent, selective, and orally active cysteinyl leukotriene type 1 receptor antagonist.
Uses
Used in Pharmaceutical Industry:
Methyl-Benzoate,Zafirlukast, is used as an intermediate compound for the synthesis of Zafirlukast (Z125000), which is a potent, selective, and orally active cysteinyl leukotriene type 1 receptor antagonist. This makes it a crucial component in the development of medications targeting various respiratory and inflammatory conditions.
Used in Respiratory Treatments:
Methyl-Benzoate,Zafirlukast, is used as a key component in the development of Zafirlukast, which is an effective treatment for asthma and allergic rhinitis. By acting as a leukotriene receptor antagonist, Zafirlukast helps to reduce inflammation and constriction in the airways, providing relief from respiratory symptoms.
Used in Inflammatory Condition Management:
Methyl-Benzoate,Zafirlukast, contributes to the development of Zafirlukast, which is also used in managing other inflammatory conditions such as eosinophilic esophagitis. By blocking the action of leukotrienes, Zafirlukast can help to alleviate symptoms and improve the quality of life for patients suffering from these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 107754-15-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,7,5 and 4 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 107754-15:
(8*1)+(7*0)+(6*7)+(5*7)+(4*5)+(3*4)+(2*1)+(1*5)=124
124 % 10 = 4
So 107754-15-4 is a valid CAS Registry Number.
107754-15-4Relevant articles and documents
Ferric Chloride Catalyzed 1,3-Rearrangement of (Phenoxymethyl)heteroarenes to (Heteroarylmethyl)phenols
Tang, Yingzhan,Zhuang, Kaitong,Zhang, Xinhang,Xie, Fukai,Yang, Lu,Lin, Bin,Cheng, Maosheng,Li, Dan,Liu, Yongxiang
, p. 3441 - 3451 (2020)
A highly useful and robust method to (heteroarylmethyl)phenols, derivatives of arylheteroarylmethanes, was developed based on iron(III)-catalyzed 1,3-rearrangement of (phenoxymethyl)heteroarenes. It features cheap catalyst, mild reaction conditions, short
Proton-exchanged montmorillonite-mediated reactions of hetero-benzyl acetates: Application to the synthesis of Zafirlukast
Yang, Lei,Chen, Xuan,Ni, Kaidong,Li, Yuansheng,Wu, Jianhong,Chen, Weilin,Ji, Yin,Feng, Lili,Li, Fei,Chen, Dongyin
, (2020/06/28)
Proton-exchanged montmorillonite (H-mont) with outstanding surface characteristics can provide abundant acidic sites in the mesopores, and serve as an efficient heterogeneous catalyst for the synthesis of heterocycle-containing diarylmethanes via Friedel-Crafts-like alkylation of (hetero)arenes by heterobenzyl acetates under mild reaction conditions without requiring any additives or an inert atmosphere. Using this strategy, the gram-scale synthesis of indole-containing diarylmethane 13 has been accomplished in good yield for the preparation of Zafirlukast. In addition, H-mont can be applied to the nucleophilic substitution reactions of heterobenzyl acetate 5p with a variety of alcohols and 1,3-dicarbonyl compounds.
Synthetic method of zukast intermediate
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Paragraph 0039; 0041-0042; 0044-0045; 0047-0048; 0050; 0060, (2020/04/29)
The invention discloses a synthesis method of a Zarustra intermediate. The synthesis method of the Zarustra intermediate is characterized in that by comprising the steps of a, adding 5-nitroindole toan organic solvent, slowly adding metal hydride, conduct
