1078162-71-6

Basic information

• Product Name: C₆₄H₁₀₈N₂₂O₁₈S
• CAS NO: 1078162-71-6
• Molecular Weight: 1505.76
• Mol File: 1078162-71-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₆₄H₁₀₈N₂₂O₁₈S(CAS DataBase Reference)
• NIST Chemistry Reference: C₆₄H₁₀₈N₂₂O₁₈S(1078162-71-6)
• EPA Substance Registry System: C₆₄H₁₀₈N₂₂O₁₈S(1078162-71-6)

Safety Data

• Hazardous Substances Data: 1078162-71-6(Hazardous Substances Data)

Upstream product

• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 
• 92122-45-7 Fmoc-D-Lys(BOC)-OH 
• 71989-33-8 Nα-(9-fluorenylmethoxycarbonyl)-D-serine-tert-butyl ether 
• 118488-18-9 Fmoc-D-Tyr(O-tBu)-OH 
• 167015-11-4 Fmoc-D-Cys(Trt)-OH 
• 200623-62-7 N-fluorenylmethoxycarbonyl-N’-trityl-D-glutamine 

Relevant articles and documents

A novel cell-penetrating peptide sequence derived by structural minimization of a snake toxin exhibits preferential nucleolar localization

Structural simplification of a 42-residue venom peptide by N-to-C-terminal splicing led to two sequences [YKQCHKKG-GXKKGSG, where X = nil (1) or 6-aminohexanoyl (2)], both efficiently uptaken by HeLa cells and, most interestingly, specifically localized at the nucleolus. Retro-2 was uptaken less efficiently, but a single (His → Ile) replacement recovered the translocation ability. None of the peptides were cytotoxic up to 100 μM. Enantio-1 did not translocate, suggesting that peptide uptake was receptor-mediated.