107825-28-5Relevant articles and documents
Design, synthesis and evaluation of novel 2-thiophen-5-yl-3H-quinazolin-4-one analogues as inhibitors of transcription factors NF-k{cyrillic}B and AP-1 mediated transcriptional activation: Their possible utilization as anti-inflammatory and anti-cancer ag
Giri, Rajan S.,Thaker, Hardik M.,Giordano, Tony,Williams, Jill,Rogers, Donna,Vasu, Kamala K.,Sudarsanam, Vasudevan
experimental part, p. 2796 - 2808 (2010/07/06)
In an attempt to discover novel inhibitors of NF-κB and AP-1 mediated transcriptional activation utilizing the concept of chemical lead based medicinal chemistry and bioisosterism a series of 2-(2,3-disubstituted-thiophen-5-yl)-3H-quinazolin-4-one analogs
Design, synthesis, and pharmacological evaluation of some 2-[4-morpholino]-3-aryl-5-substituted thiophenes as novel anti-inflammatory agents: Generation of a novel anti-inflammatory pharmacophore
Pillai, Ajay D.,Rathod, Parendu D.,Xavier, Franklin P.,Vasu, Kamala K.,Padh, Harish,Sudarsanam, Vasudevan
, p. 4667 - 4671 (2007/10/03)
We report the synthesis and pharmacological evaluation of some novel 2-morpholino-3-aryl-5-substituted thiophenes, as possible anti-inflammatory leads. The studies culminate in the generation of a novel pharmacophore, which will enable the designing of be
