1078728-26-3

Basic information

• Product Name: C₂₅H₂₃N₃O₃
• CAS NO: 1078728-26-3
• Molecular Weight: 413.476
• Mol File: 1078728-26-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₃N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₃N₃O₃(1078728-26-3)
• EPA Substance Registry System: C₂₅H₂₃N₃O₃(1078728-26-3)

Safety Data

• Hazardous Substances Data: 1078728-26-3(Hazardous Substances Data)

Upstream product

• 445012-62-4 4-(pyridin-3-yl)benzene-1,2-diamine 
• 328233-08-5 trans-3-oxospiro[isobenzofuran-1(3H),1'-cyclohexane]-4'-carboxylic acid 

Relevant articles and documents

Syntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1′-cyclohexan]-4′-yl]benzimidazole NPY Y5 receptor antagonists

Syntheses and structure-activity relationships of a novel class of 2-[3-oxospiro[isobenzofuran-1(3H),1′-cyclohexan]-4′-yl]benzimidazole NPY Y5 receptor antagonists are described. Optimization of the lead compound 2a by incorporating substituents into the 5-position or into both the 5- and 6-positions of the benzimidazole core part led to the identification of 5-(5-methyl-1,2,4-oxadiazol-2-yl)benzimidazole (2r: IC50 = 3.3 nM) and 5-(2-methyltetrazol-5-yl)benzimidazole (2u: IC50 = 5.9 nM), both of which are potent, selective, and orally bioavailable Y5 receptor antagonists. Crown Copyright