1078736-39-6

Basic information

• Product Name: (R)-2-[3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid
• Synonyms: (R)-2-[3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid
• CAS NO: 1078736-39-6
• Molecular Weight: 429.396
• Mol File: 1078736-39-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-[3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-[3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid(1078736-39-6)
• EPA Substance Registry System: (R)-2-[3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid(1078736-39-6)

Safety Data

• Hazardous Substances Data: 1078736-39-6(Hazardous Substances Data)

Upstream product

• 1078736-38-5 (R)-2-[3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid benzyl ester 

Downstream Products

• 1078736-49-8 (R)-[3-{5-(pyridin-2-ylmethyl)carbamoyl-4,5-dihydropyrazol-1-yl}-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester 
• 1078736-42-1 (R)-2-[3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-ethoxycarbonylphenyl ester 
• 1078736-52-3 (R)-[3-oxo-3-[5-(4-sulfamoylbenzylcarbamoyl)-4,5-dihydropyrazol-1-yl]-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester 
• 1078736-44-3 (R)-[3-(5-carbamoyl-4,5-dihydropyrazol-1-yl)-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester 
• 1078736-13-6 C₁₄H₁₄F₃N₃O₃*ClH 
• 1078736-54-5 (R)-{3-[({2-[3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl}amino)methyl]phenoxy}acetic acid ethyl ester 
• 1078736-61-4 (R)-{4-[{2-[3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl}amino]phenoxy}-(S)-isopropylacetic acid ethyl ester 
• 1078736-83-0 (R)-{4-[{2-[3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl}amino]phenoxy}-(R)-isopropylacetic acid ethyl ester 
• 1078736-50-1 (R)-[3-{5-[(1H-benzimidazol-2-ylmethyl)carbamoyl]-4,5-dihydropyrazol-1-yl}-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester 
• 1078736-55-6 (R)-[3-[5-(4-morpholin-4-ylphenylcarbamoyl)-4,5-dihydropyrazol-1-yl]-3-oxo-1-(2,4,5-trifluorobenzyl)propyl]carbamic acid tert-butyl ester 
• 1078736-43-2 (R)-2-[3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carboxylic acid 4-(methoxycarbonylmethyl)phenyl ester 
• 1078736-46-5 (R)-4-[({2-[3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl}amino)methyl]benzoic acid methyl ester 
• 1078736-53-4 (R)-{4-[({2-[3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl}amino)methyl]phenoxy}acetic acid ethyl ester 
• 1078736-58-9 (R)-{4-[{2-[3-tert-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)butyryl]-3,4-dihydro-2H-pyrazole-3-carbonyl}amino]phenoxy}acetic acid ethyl ester 

Relevant articles and documents

Synthesis and biological evaluation of pyrazoline analogues with β-amino acyl group as dipeptidyl peptidase IV inhibitors

A series of pyrazoline derivatives with β-amino acyl group were synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV. Several pyrazoline derivatives exhibited submicromolar inhibitory activities against DPP-IV. X-ray co-crystal structure of initial hit compound 1h was determined. Among this series, carboxylic acid substituted pyrazoline derivative 2u was the most active and greatly decreased the inhibitory activity toward CYP3A4 enzyme.