107920-76-3Relevant articles and documents
Discovery of AL-GDa62 as a Potential Synthetic Lethal Lead for the Treatment of Gastric Cancer
Beetham, Henry,Bougen-Zhukov, Nicola,Cameron, Scott A.,Evans, Gary B.,Fraser, Michael G.,Guilford, Parry J.,Harris, Lawrence D.,Luxenburger, Andreas,Schmidt, Dorian
, p. 18114 - 18142 (2021/12/17)
Diffuse gastric cancer and lobular breast cancer are aggressive malignancies that are frequently associated with inactivating mutations in the tumor suppressor gene CDH1. Synthetic lethal (SL) vulnerabilities arising from CDH1 dysfunction represent attrac