108011-90-1

Basic information

• Product Name: 2-(2,4-Dichlorophenyl)-5-phenyloxazole
• Synonyms: 2-(2,4-Dichlorophenyl)-5-phenyloxazole
• CAS NO: 108011-90-1
• Molecular Weight: 290.149
• Mol File: 108011-90-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(2,4-Dichlorophenyl)-5-phenyloxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-Dichlorophenyl)-5-phenyloxazole(108011-90-1)
• EPA Substance Registry System: 2-(2,4-Dichlorophenyl)-5-phenyloxazole(108011-90-1)

Safety Data

• Hazardous Substances Data: 108011-90-1(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 884866-01-7 1-(4-methylbenzensulfonyl)-4-phenyl-1H-1,2,3-triazole 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 98-86-2 acetophenone 
• 1074-12-0 phenylglyoxal hydrate 
• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 
• 95-00-1 2,4-dichloro-benzenemethanamine 

Relevant articles and documents

N -Bromosuccinimide as a Brominating Agent for the Transformation of N -H (or N -Benzyl) Ketoaziridines into Oxazoles

A novel procedure for the direct synthesis of 2,5-diaryloxazoles starting from N-H ketoaziridines is described. The method proceeds via the in situ formation of N-bromoketoaziridines in the presence of N-bromosuccinimide followed by the generation of intermediate azomethine ylides. A plausible mechanism for this transformation is proposed.

Synthesis method of oxazole heterocyclic compound

The invention belongs to the technical field of organic synthesis and medicines, and particularly relates to a synthesis method of an oxazole heterocyclic compound. Aryl aldehyde and a triazole derivative are used as raw materials and are heated to react in the presence of trichloromethane and rhodium acetate catalysts to obtain the oxazole heterocyclic compound. By using the method provided by the invention, under the condition of heating and stirring, the oxazole heterocyclic derivative can be obtained at a relatively high yield after reaction for 3-12 hours. According to the method disclosed by the invention, the oxazole heterocyclic derivative is simply, conveniently and efficiently synthesized by using simple and easily available raw materials through a one-step method, and a simple and efficient new synthesis method with wide substrate universality is provided for synthesizing the oxazole heterocyclic derivative.

C-C bond cleavage of keto-aziridines; synthesis of oxazoles via regio-controlled ring expansion

The ring expansion of keto-aziridines to the corresponding 2,5-diaryloxazoles in the presence of iodine in refluxing dimethyl sulfoxide, is described. A plausible mechanism for the synthesis of 2,5-diaryloxazoles is proposed.