1080622-86-1

Basic information

• Product Name: CP466722
• Synonyms: CP466722;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine;2-(6,7-dimethoxyquinazolin-4-yl)-5-(pyridin-2-yl)-2H-1,2,4-triazol-3-amine;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine CP 466722;2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine;1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine
• CAS NO: 1080622-86-1
• Molecular Formula: C17H15N7O2
• Molecular Weight: 349.35
• EINECS: -0
• Product Categories: Inhibitors
• Mol File: 1080622-86-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 642.3±65.0 °C(Predicted)
• Appearance: white to beige/
• Density: 1.48
• Storage Temp.: 2-8°C
• Solubility: DMSO: soluble0.5mg/mL, clear (warmed)
• PKA: 0.00±0.19(Predicted)
• CAS DataBase Reference: CP466722(CAS DataBase Reference)
• NIST Chemistry Reference: CP466722(1080622-86-1)
• EPA Substance Registry System: CP466722(1080622-86-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 1080622-86-1(Hazardous Substances Data)

Usage

Description

CP466722 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase, which plays a crucial role in the cellular response to DNA damage. It is a competitive, reversible inhibitor that effectively inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of ATM targets such as SMC1, Chk2, and p53 in HeLa cells. CP466722 is selective for ATM over other kinases like PI3K and PIKK, making it a potential candidate for therapeutic applications in cancer treatment.

Uses

Used in Cancer Treatment:
CP466722 is used as an inhibitor of ATM kinase for its potential application in cancer treatment. By inhibiting ATM kinase, it can decrease cell survival in response to ionizing radiation in HeLa cells and exhibit cytotoxic effects on breast cancer cells, such as MCF-7 and SKBr-3, with IC50s of 16.92 and 12.78 μM, respectively. This suggests that CP466722 may have therapeutic potential in the treatment of certain types of cancer, particularly those involving ATM kinase dysregulation.
Used in Radiotherapy:
CP466722 is used as a radiosensitizer in radiotherapy to enhance the effectiveness of ionizing radiation in cancer treatment. By inhibiting ATM kinase, it can increase the sensitivity of cancer cells to radiation, potentially leading to improved treatment outcomes for patients undergoing radiotherapy.
Used in Research:
CP466722 is used as a research tool for studying the role of ATM kinase in various cellular processes, particularly those related to DNA damage response and cell cycle regulation. Its selective inhibition of ATM kinase makes it a valuable compound for investigating the molecular mechanisms underlying the cellular response to DNA damage and the development of cancer.

references

[1]. guo, k., et al., development of a cell-based, high-throughput screening assay for atm kinase inhibitors. j biomol screen, 2014. 19(4): p. 538-46.[2]. nadkarni, a., et al., atm inhibitor ku-55933 increases the tmz responsiveness of only inherently tmz sensitive gbm cells. j neurooncol, 2012. 110(3): p. 349-57. [3]. rainey, m.d., et al., transient inhibition of atm kinase is sufficient to enhance cellular sensitivity to ionizing radiation. cancer res, 2008. 68(18): p. 7466-74.