1081-15-8

Basic information

• Product Name: FORMALDEHYDE 2,4-DINITROPHENYLHYDRAZONE
• Synonyms: FORMALDEHYDE (DNPH DERIVATIVE);FORMALDEHYDE-DNPH, 5X1ML, ACN 100UG/ML;FORMALDEHYDE 2,4-DINITROPHENYLHYDRAZONE, ENVIRONMENTAL STANDARD, 99%;73517, Formaldehyde 2,4-dinitrophenylhyd razone (purity);FORMALDEHYDE-DNPH, 1X1ML, ACN 100UG/ML;FORMALDEHYDE-2,4-DNPH, 100MG, NEAT;FORMALDEHYDE 2,4-DINITROPHENYLHYDRAZONE 98+% ( SEA ONLY);formaldehyde-2,4-dinitrophenylhydrazone solution
• CAS NO: 1081-15-8
• Molecular Formula: C₇H₆N₄O₄
• Molecular Weight: 210.15
• EINECS: 200-835-2
• Product Categories: Alpha Sort;E-LAlphabetic;FM - FZ;Volatiles/ Semivolatiles;Air MonitoringAlphabetic;Aldehydes/DNPH;Application CRMs;Certified Reference Materials (CRMs);FM - FZChemical Class;NeatsCertified Reference Materials (CRMs);Occupational Hygiene CRM;Aldehyde/DNPHPassive/Diffusive Sampling;Calibration StandardsAlphabetic;California Air Resources Board (CARB) Methods;FM - FZInternational Standards;Single Component Carbonyl-DNPH Solutions;Air Monitoring Standards;Chromatography;DSD-DNPH Passive Sampling Device;F;E-F;Stains and Dyes;Stains&Dyes, A to
• Mol File: 1081-15-8.mol
• Article Data: 33

Chemical Properties

• Melting Point: 153-156°C
• Boiling Point: 357.8°Cat760mmHg
• Flash Point: 2 °C
• Appearance: /
• Density: 1.54g/cm³
• Vapor Pressure: 2.67E-05mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: 0-6°C
• Solubility: Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 10.30±0.10(Predicted)
• Stability: Light Sensitive, Shock Sensitive
• BRN: 750330
• CAS DataBase Reference: FORMALDEHYDE 2,4-DINITROPHENYLHYDRAZONE(CAS DataBase Reference)
• NIST Chemistry Reference: FORMALDEHYDE 2,4-DINITROPHENYLHYDRAZONE(1081-15-8)
• EPA Substance Registry System: FORMALDEHYDE 2,4-DINITROPHENYLHYDRAZONE(1081-15-8)

Safety Data

• Hazard Codes: Xi,Xn,F
• Statements: 36/37/38-36-20/21/22-11-22
• Safety Statements: 26-36/37/39-36-36/37-16
• RIDADR: UN 1648 3/PG 2
• WGK Germany: 3
• RTECS: AB2826500
• Hazardous Substances Data: 1081-15-8(Hazardous Substances Data)

Usage

Description

FORMALDEHYDE 2,4-DINITROPHENYLHYDRAZONE is a dinitrophenylhydrazone (DNPH) derivative of an aliphatic aldehyde, specifically formaldehyde, which is commonly found in mainstream cigarette smoke. It is a chemical compound that has been identified for its presence in the environment and its potential impact on human health.

Uses

Used in Environmental Chemistry:
FORMALDEHYDE 2,4-DINITROPHENYLHYDRAZONE is used as a chemical marker for the detection and analysis of aldehydes, particularly formaldehyde, in various environmental samples. The compound serves as an indicator of the presence of harmful aldehydes in cigarette smoke and other polluted environments.
Used in Analytical Chemistry:
FORMALDEHYDE 2,4-DINITROPHENYLHYDRAZONE is used as a reagent in analytical chemistry for the identification and quantification of aldehydes. Its formation with aldehydes allows for the detection and measurement of these compounds in various samples, including air, water, and biological tissues.
Used in Toxicology:
FORMALDEHYDE 2,4-DINITROPHENYLHYDRAZONE is used as a tool in toxicology research to study the effects of aldehydes, such as formaldehyde, on human health. The compound can help researchers understand the mechanisms of toxicity and potential health risks associated with exposure to these harmful substances.
Used in Pharmaceutical Industry:
FORMALDEHYDE 2,4-DINITROPHENYLHYDRAZONE may be used in the pharmaceutical industry as a starting material or intermediate in the synthesis of various drugs and pharmaceutical compounds. Its unique chemical properties make it a valuable component in the development of new medications and therapies.
Used in Quality Control:
FORMALDEHYDE 2,4-DINITROPHENYLHYDRAZONE is used in quality control processes to ensure the safety and purity of products, particularly in the context of cigarette manufacturing. By monitoring the levels of this compound, manufacturers can better control the presence of harmful aldehydes in their products and minimize potential health risks for consumers.

InChI:InChI=1/C7H6N4O4/c1-8-9-6-3-2-5(10(12)13)4-7(6)11(14)15/h2-4,9H,1H2

Upstream product

• 67-56-1 methanol 
• 100621-95-2 phenoxymethyl benzoate 
• 119-26-6 (2,4-dinitro-phenyl)-hydrazine 
• 1426658-55-0 2-(2-chloroethyl)-N-methyl-1,2-bis(methylsulfonyl)-N-nitrosohydrazinecarboxamide 
• 1426658-59-4 N-(2-chloroethyl)-2-methyl-1,2-bis(methylsulfonyl)-N-nitrosohydrazinecarboxamide 
• 107-21-1 ethylene glycol 
• 57-55-6 propylene glycol 
• 50-00-0 formaldehyd 
• 78-85-3 2-methylpropenal 
• 38433-80-6 3-hydroxy-2-methylpropanal 
• 18516-18-2 3-hydroxy-2-(hydroxymethyl)-2-methylpropanal 
• 123-38-6 propionaldehyde 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 2319-38-2 triphenylsilyl hydroperoxide 

Downstream Products

• 41931-22-0 (2,4-dinitro-phenyl)-[1,3,5]dioxazinan-5-yl-amine 

Relevant articles and documents

Quantitative online analysis of liquid-phase products of methanol oxidation in aqueous sulfuric acid solutions using electrospray ionization mass spectrometry

We describe a novel method and setup for quantitative online analysis of the liquid-phase methanol oxidation products in acidic aqueous solutions by electrospray ionization mass spectrometry (ESI-MS). This includes a specially designed flow system, which allows continuous online mixing, derivatization, extraction, separation, and quantitative detection within ca. 3 min. For electrospray ionization of formaldehyde, it is first online-derivatized by 2,4-dinitrophenyl hydrazine to form the easily ionizable 2,4-dinitrophenyl hydrazone. Then, both formic acid and derivatized formaldehyde are online extracted into an immiscible organic phase, which, after separation from the aqueous phase, is piped to the ESI-MS for analysis. This strategy ensures complete removal of the highly corrosive sulfuric acid from the analyte and allows the liquid-phase methanol oxidation reaction (MOR) products (formaldehyde and formic acid) to be quantitatively detected by ESI-MS. Finally, the potential of this method for online analysis in electroanalysis and electrocatalysis is discussed.

Determination of sub-part-per-million levels of formaldehyde in air using active or passive sampling on 2,4-dinitrophenylhydrazine-coated glass fiber filters and high-performance liquid chromatography

Formaldehyde is sampled from air with the use of a standard miniature glass fiber filter impregnated with 2,4-dinitrophenylhydrazine and phosphoric acid. The formaldehyde hydrazone is desorbed from the filter with acetonitrile and determined by high-perfo

Intramolecular oxidative o-demethylation in a per-o-methylated β-cyclodextriniron porphyrin inclusion complex in aqueous solution

The reaction of a supramolecular heme enzyme model (methemoCD2), a 1:1 inclusion complex of 5,10,15,20-tetrakis(4-sulfonatophenyl)porphinatoiron(III) (FeIIITPPS) and a per-Omethylated β-cyclodextrin dimer having a OCH2PyCH2O (Py: pyridin-3,5-diyl) linker (Py2CD), with peroxy acid (m-chloroperbenzoic acid or peracetic acid) caused intramolecular mono- and di-O-demethylations of the OCH3 group(s) of Py2CD. The O-demethylation seemed to proceed through the hydroxylation of a CH bond of OCH3 by an oxoiron(IV) porphyrin π-cation radical (O=Fe IVP·+).

Highly effective C-C bond cleavage of lignin model compounds

A highly effective method is developed for the C-C bond cleavage of lignin model compounds. The inert Cα-Cβ or Cα-Cphenyl bond of oxidized lignin model compounds was successfully converted to an active ester bond through the classic organic name reaction, Baeyer-Villiger (BV) oxidation, and thus acetal esters and aryl esters were produced in high yields (up to 99%) at room temperature. Next, K2CO3 catalyzed the alcoholysis of the resulting ester products at 45 °C, affording various useful chemical platforms in excellent yields (up to 99%), such as phenols and multifunctional esters. This method uses commercially available reagents, is transition-metal free and simple, but highly effective, and involves mild reaction conditions.