108124-77-2

Basic information

• Product Name: 3H-Pyrazol-3-one, 2-(3-chlorophenyl)-2,4-dihydro-5-phenyl-
• Synonyms: ZINC04427449;2-(3-chlorophenyl)-5-phenyl-4H-pyrazol-3-one;3-phenyl-1-(3-chlorophenyl)pyrazol-5(4H)-one;2-(3-CHLORO-PHENYL)-5-PHENYL-2,4-DIHYDRO-PYRAZOL-3-ONE;2-(3-Chlorophenyl)-5-phenyl-2,4-dihydro-3H-pyrazol-3-one
• CAS NO: 108124-77-2
• Molecular Formula: C₁₅H₁₁ClN₂O
• Molecular Weight: 270.71
• Mol File: 108124-77-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3H-Pyrazol-3-one, 2-(3-chlorophenyl)-2,4-dihydro-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-Pyrazol-3-one, 2-(3-chlorophenyl)-2,4-dihydro-5-phenyl-(108124-77-2)
• EPA Substance Registry System: 3H-Pyrazol-3-one, 2-(3-chlorophenyl)-2,4-dihydro-5-phenyl-(108124-77-2)

Safety Data

• Hazardous Substances Data: 108124-77-2(Hazardous Substances Data)

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 14763-20-3 3-chlorophenyl hydrazine 
• 2312-23-4 m-chlorophenylhydrazine hydrochloride 

Downstream Products

• 1311144-34-9 C₃₁H₂₀Cl₂N₄O₂ 

Relevant articles and documents

Targeting fungal virulence factor by small molecules: Structure-based discovery of novel secreted aspartic protease 2 (SAP2) inhibitors

Secreted aspartic protease 2 (SAP2), a kind of virulence factor, is an emerging new antifungal target. Using docking-based virtual screening and structure-based inhibitor design, a series of novel SAP2 inhibitors were successfully identified. Among them, indolone derivative 24a showed potent SAP2 inhibitory activity (IC50 = 0.92 μM). It blocked fungi biofilm and hypha formation by down-regulating the expression of genes SAP2, ECE1, ALS3 and EFG1. As a virulence factor inhibitor, compound 24a was inactive in vitro and showed potent in vivo efficacy in a murine model of invasive candidiasis. It represents a promising lead compound for the discovery of novel antifungal agents.

Asymmetric [3 + 3] Annulation of Copper-Allenylidenes with Pyrazolones: Synthesis of Chiral 1,4-Dihydropyrano[2,3- c]pyrazoles

The copper-catalyzed asymmetric [3 + 3] annulation of ethynyl benzoxazinanones with pyrazolones has been achieved, providing simple access to 1,4-dihydropyrano[2,3-c]pyrazole derivatives in moderate to excellent yields with excellent enantioselectivities (up to 99% ee). Compared with previous annulation reactions of copper-allenylidenes from ethynyl benzoxazinanones, the current reaction fused the three carbon atoms of the propargyl moiety into a heterocyclic framework.