108133-60-4

Basic information

• Product Name: 4-{[1-(3-Fluoro-phenyl)-meth-(E)-ylidene]-amino}-benzoic acid
• Synonyms: 4-{[1-(3-Fluoro-phenyl)-meth-(E)-ylidene]-amino}-benzoic acid
• CAS NO: 108133-60-4
• Molecular Weight: 243.237
• Mol File: 108133-60-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-{[1-(3-Fluoro-phenyl)-meth-(E)-ylidene]-amino}-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{[1-(3-Fluoro-phenyl)-meth-(E)-ylidene]-amino}-benzoic acid(108133-60-4)
• EPA Substance Registry System: 4-{[1-(3-Fluoro-phenyl)-meth-(E)-ylidene]-amino}-benzoic acid(108133-60-4)

Safety Data

• Hazardous Substances Data: 108133-60-4(Hazardous Substances Data)

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 456-48-4 3-Fluorobenzaldehyde 

Downstream Products

• 1190945-00-6 4-(1-(3-fluorophenyl)-5-(6-methoxynaphthalen-2-yl)-3-oxopentylamino)benzoic acid 
• 150-13-0 4-amino-benzoic acid 
• 456-48-4 3-Fluorobenzaldehyde 

Relevant articles and documents

Synthesis of novel β-amino ketones containing a p-aminobenzoic acid moiety and evaluation of their antidiabetic activities

The synthesis of two series of β-amino ketones containing a p-aminobenzoic acid moiety (TM-1 and TM-2) using a modified protocol of the Mannich reaction is reported. The molecular structures of a total of tweenty three new target compounds were characterized by 1H NMR, 13C NMR, ESI-MS and HR-MS. Subsequently, their antidiabetic activities were screened in vitro. The α-glucodase inhibition (α-GI) activity of compound 1e reached a remarkable level of 66.50%. The peroxisome proliferator-activated receptor (PPAR) relative activation activities of six compounds are above 80%, and in particular 2i displays an unprecedentedly high PPAR of 130.91%. The structure-activity relationships of the compounds were established. 2i is also subject to further in-depth investigation.