1082208-85-2Relevant articles and documents
PALLADIUM-CATALYZED ORTHO-FLUORINATION
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Page/Page column 12, (2012/03/26)
A new method of ortho-fluorination where an aryl C—H bond is directly replaced by an aryl C-F bond in a palladium-catalyzed reaction is provided. The method includes the ortho-fluorination of a triflamide protected benzylamine, a palladium catalyst, such as Pd(OTf)2, a fluorinating reagent such as N-fluoro-2,4,6-trimethylpyridinium triflate, and a ligand to promote the reaction such as N-methylpyrrolidinone (NMP).
Convenient synthesis of primary sulfonamides
Greenfield, Alexander,Grosanu, Cristina
body text, p. 6300 - 6303 (2009/04/06)
An efficient protocol for a one-pot synthesis of mono-sulfonamides has been developed. It features utilization of excess of sulfonylating agent followed by base mediated recovery of the primary sulfonamide.