1083-27-8Relevant articles and documents
Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid
Patel, Chirag K.,Owen, Caroline P.,Ahmed, Sabbir
, p. 605 - 609 (2004)
In our search for potent inhibitors of the enzyme estrone sulfatase (ES), we have undertaken the synthesis and biochemical evaluation of a range of esters of 4-[(aminosulfonyl)oxy] benzoic acid. The results of the study show that the synthesised compounds possess potent inhibitory activity, indeed the cyclooctyl derivative was found to be more potent than 667-COUMATE, which is currently undergoing clinical trials.
Iron-catalyzed C[sbnd]C bond activation/C[sbnd]O bond formation: Direct conversion of ketones to esters
Arzumanyan, Ashot V.
, p. 4667 - 4671 (2017)
The iron-catalyzed oxidative activation of the (O)C[sbnd]C bond in ketones has been developed. This method enables direct synthesis of esters by the reaction between ketones and alcohols via conversion of the (O)C[sbnd]C bond to the (O)C[sbnd]O bond. The
Single-Step Dual Functionalization: One-Pot Bromination-Cross-Dehydrogenative Esterification of Hydroxy Benzaldehydes with CCl 3 Br - A Comparison with Selectfluor
Talukdar, Ranadeep
supporting information, p. 1713 - 1718 (2019/08/28)
Bromination of phenolic compounds without directly using molecular bromine possesses much importance. In this article an Ir III /CCl 3 Br-assisted single-step double functionalization of hydroxy benzaldehydes is reported. It involves simultaneous esterification of the aldehyde group and bromination of the aryl ring of phenolic aldehydes in one-pot. The reaction proceeds under mild conditions in the presence of 445 nm blue LED light to obtain highly functionalized bromo hydroxy benzoates in moderate to good yields. In comparison, Selectfluor as an oxidant gives only non-bromo phenolic esters.
METHOD FOR PRODUCING HEXYL 4-HYDROXYBENZOATE
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Paragraph 0062; 0063; 0064; 0065; 0066; 0067; 0068-0070, (2018/07/28)
PROBLEM TO BE SOLVED: To provide a production method that makes it possible to obtain hexyl 4-hydroxybenzoate with excellent productivity, reduced by-products, and high yield, and a production method that makes it possible to obtain high-purity hexyl 4-hydroxybenzoate. SOLUTION: The present invention provides a method for producing hexyl 4-hydroxybenzoate represented by formula (1), including the step of making a reaction occur between hexyl 4-hydroxybenzoate of 1 molar equivalent and 1-hexanol of 0.8-3.0 molar equivalents in the presence of an acid catalyst. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT