108306-53-2

Basic information

• Product Name: 4-BROMO-2-(TRIMETHYLSILYL)THIAZOLE
• Synonyms: 2-TRIMETHYLSILYL-4-BROMOTHIAZOLE;4-BROMO-2-TRIMETHYLSILANYL-THIAZOLE;4-BROMO-2-(TRIMETHYLSILYL)THIAZOLE;(4-Bromo-1,3-thiazol-2-yl)trimethylsilane;4-Bromo-2-(trimethylsilyl)-1,3-thiazole;4-BroMo-2-(triMethylsilyl)thiazole 95%;4-Bromo-2-(trimethylsilyl)
• CAS NO: 108306-53-2
• Molecular Formula: C6H10BrNSSi
• Molecular Weight: 236.2
• Product Categories: Halogenated;Organohalides;Thiazole;Building Blocks;C3 to C7;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Thiazoles
• Mol File: 108306-53-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 226.1 °C at 760 mmHg
• Flash Point: 82°C
• Appearance: Pale yellow clear liquid
• Density: 1.384g/mLat 25℃
• Vapor Pressure: 0.125mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 0.14±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-2-(TRIMETHYLSILYL)THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-(TRIMETHYLSILYL)THIAZOLE(108306-53-2)
• EPA Substance Registry System: 4-BROMO-2-(TRIMETHYLSILYL)THIAZOLE(108306-53-2)

Safety Data

• Hazard Codes: Xi
• RIDADR: NA 1993 / PGIII
• WGK Germany: 1
• Hazardous Substances Data: 108306-53-2(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-(trimethylsilyl)thiazole is a chemical compound with the molecular formula C6H9BrNSiS. It is a thiazole derivative with a trimethylsilyl group attached to the nitrogen atom and a bromine atom attached to the thiazole ring. 4-BROMO-2-(TRIMETHYLSILYL)THIAZOLE is commonly used as a building block in organic synthesis and is often employed as a reagent in the preparation of various pharmaceuticals, agrochemicals, and materials science applications. It is also known for its use in the modification of biomolecules and as a reagent in the preparation of thiazole-based fluorescent dyes. 4-Bromo-2-(trimethylsilyl)thiazole is a versatile compound that finds applications in a wide range of chemical and biological processes.

InChI:InChI=1/C6H10BrNSSi/c1-10(2,3)6-8-5(7)4-9-6/h4H,1-3H3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 4175-77-3 2,4-dibromo-1,3-thiazole 
• 34259-99-9 4-bromo-1,3-thiazole 

Downstream Products

• 108306-60-1 4-Iodothiazole 
• 108306-56-5 4-Bromo-2-iodothiazole 
• 34259-99-9 4-bromo-1,3-thiazole 
• 108306-55-4 2,4-Diiodo-thiazole 
• 41731-34-4 4-Iodo-2-bromothiazole 

Relevant articles and documents

Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for beta-secretase modulation

The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles

THIAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES

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Synthesis of (Trimethylsilyl)thiazoles and Reactions with Carbonyl Compounds. Selectivity Aspects and Synthetic Utility

Synthetic routes to all possible regioisomeric mono- and bis(trimethylsilyl)thiazoles as well as to the tris(trimethylsilyl) derivative via lithiation-silylation sequences of the thiazole ring followed by selective protodesilylation in some cases are described. (Trimethylsilyl)thiazoles serve as thiazolyl donor synthons upon reaction with carbonyl compounds (ketenes, acyl chlorides, aldehydes) for the preparation of mono- and bis-substituted thiazoles in very good yields.Carbodesilylation occurs more readily at the 2- than 5-position, whereas no reaction takes place at the 4-position.A mechanism via a thiazolium 2-ylide as an intermediate is suggested for the carbodesilylation at the 2-position.