1083067-23-5Relevant articles and documents
Structure-activity relationships study of bastadin 6, an anti-angiogenic brominated-tyrosine derived metabolite from marine sponge
Kotoku, Naoyuki,Hiramatsu, Atsushi,Tsujita, Hiroaki,Hirakawa, Yoichi,Sanagawa, Mami,Aoki, Shunji,Kobayashi, Motomasa
experimental part, p. 568 - 577 (2009/04/06)
A structure-activity relationship (SAR) study of bastadin 6 (1), a brominated tyrosine-derived metabolite from Indonesian marine sponge having a potent anti-angiogenic activity, was executed. The syntheses and their biological evaluation of the oxime-modified analogues and bromine-modified analogues revealed that both the oxime moieties and bromine atoms in bastadin 6 (1) play an important role to show the potent and selective anti-proliferative activity against human umbilical vein endothelial cells (HUVECs).