1083168-92-6

Basic information

• Product Name: 2,3-Dimethoxypyridine-5-boronic acid,pinacol ester
• Synonyms: 2,3-Dimethoxypyridine-5-boronic acid,pinacol ester;5,6-diMethoxypyridin-3-ylboronic acid pinacol ester;5,6-Dimethoxypyridine-3-boronic acid pinacol ester;2,3-Dimethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)
• CAS NO: 1083168-92-6
• Molecular Formula: C₁₃H₂₀BNO₄
• Molecular Weight: 283.12848
• Mol File: 1083168-92-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,3-Dimethoxypyridine-5-boronic acid,pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dimethoxypyridine-5-boronic acid,pinacol ester(1083168-92-6)
• EPA Substance Registry System: 2,3-Dimethoxypyridine-5-boronic acid,pinacol ester(1083168-92-6)

Safety Data

• Hazardous Substances Data: 1083168-92-6(Hazardous Substances Data)

Usage

General Description

2,3-Dimethoxypyridine-5-boronic acid, pinacol ester is a chemical compound commonly used in the field of organic synthesis. Its molecular formula is C12H18BNO4, which often appears as a light yellow to yellow solid. This organic compound is involved in Suzuki-Miyaura cross-coupling reactions, known for the formation of carbon-carbon bonds. The boronic acid, pinacol ester group provides the critical component that makes this reaction possible. Proper handling is essential as it may cause skin and eye irritation, and could be harmful if inhaled. Additionally, like most boronic acids, it needs suitable storage conditions due to its sensitivity to air and moisture.

Upstream product

• 52605-97-7 2,3-dimethoxypyridine 
• 52605-98-8 5-bromo-2,3-dimethoxypyridine 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1315534-54-3 2-(3-(5-(5,6-dimethoxypyridin-3-yl)-1-oxoisoindolin-2-yl)phenyl)acetonitrile 
• 1186310-85-9 5, 6-dimethoxypyridin-3-ol 
• 1383988-61-1 2-amino-6-[5,6-bis(methyloxy)-3-pyridinyl]-3-phenyl-4(3H)-quinazolinone 
• 1315544-59-2 methyl 2-(bromomethyl)-4-(5,6-dimethoxy-3-pyridyl)-6-methylbenzoate 
• 1315545-11-9 C₁₆H₁₅BrClNO₄ 
• 1315544-61-6 methyl 2-chloro-4-(5,6-dimethoxy-3-pyridyl)-6-methylbenzoate 
• 1315544-58-1 methyl 4-(5,6-dimethoxy-3-pyridyl)-2,6-dimethylbenzoate 

Relevant articles and documents

Contorted Heteroannulated Tetraareno[a,d,j,m]coronenes

Fused polycyclic aromatic compounds are interesting materials for organic electronics applications. To fine-tune photophysical or electrochemical properties, either various substituents can be attached or heteroatoms (such as N or S) can be incorporated into the fused aromatic backbone. Coronenes and heterocoronenes are promising compounds in this respect. Up until now, the possibilities for varying the attached fused heteroaromatics at the coronene core were quite limited, and realizing both electron-withdrawing and -donating rings at the same time was very difficult. Here, a series of pyridine, anisole and thiophene annulated tetraareno[a,d,j,m]coronenes has been synthesized by a facile two-step route that is a combination of Suzuki-Miyaura cross-coupling and a following cyclization step, starting from three different diarenoperylene dibromides. The contorted molecular π-planes of the obtained cata-condensed tetraarenocoronenes were analyzed by single-crystal X-ray crystallography, and the photophysical and electrochemical properties were systematically investigated by UV/Vis spectroscopy and cyclovoltammetry.

INHIBITORS OF PI3 KINASE

The present invention relates to compounds of Formula I, II or III or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein

MODULATORS OF CFTR

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.