1084892-90-9

Basic information

• Product Name: 5-methyl-1H-indole-2,3-dione 3-[N-(2-bromophenyl)thiosemicarbazone]
• Synonyms: 5-methyl-1H-indole-2,3-dione 3-[N-(2-bromophenyl)thiosemicarbazone]
• CAS NO: 1084892-90-9
• Molecular Weight: 389.275
• Mol File: 1084892-90-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-methyl-1H-indole-2,3-dione 3-[N-(2-bromophenyl)thiosemicarbazone](CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-1H-indole-2,3-dione 3-[N-(2-bromophenyl)thiosemicarbazone](1084892-90-9)
• EPA Substance Registry System: 5-methyl-1H-indole-2,3-dione 3-[N-(2-bromophenyl)thiosemicarbazone](1084892-90-9)

Safety Data

• Hazardous Substances Data: 1084892-90-9(Hazardous Substances Data)

Upstream product

• 608-05-9 5-methyl-indole-2,3-dione 
• 25688-12-4 N-(2-bromophenyl)hydrazinecarbothioamide 

Relevant articles and documents

Synthesis and antituberculosis activity of 5-methyl/trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazone derivatives

New series of 5-methyl/trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazones 3a-t, 1-methyl-5-methyl/trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazones 4a-y and 5-trifluoromethoxy-1-morpholinomethyl-1H-indole-2,3-dione 3-thiosemicarbazones 5a-m were synthesized. The structures of the synthesized compounds were confirmed by spectral data and elemental analysis. The new 5-methyl/trifluoromethoxy-1H-indole-2,3-dione derivatives, along with previously synthesized 5-methyl-1H-indole-2,3-dione 3-thiosemicarbazones 6a-l, were evaluated for in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv. 5-Methyl-1H-indole-2,3-dione 3-thiosemicarbazones (3b, 3d, 3f, 6c, 6d, and 6f), 5-trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazones (3q-s) and 5-trifluoromethoxy-1-morpholinomethyl-1H-indole-2,3-dione 3-thiosemicarbazones (5e and 5j-l) were found to be the most potent inhibitors of M. tuberculosis growth described in this study.