108491-55-0

Basic information

• Product Name: benzyl (R)-2-oxoazepan-3-ylcarbamate
• Synonyms: benzyl (R)-2-oxoazepan-3-ylcarbamate
• CAS NO: 108491-55-0
• Molecular Formula: C₁₄H₁₈N₂O₃
• Molecular Weight: 262.30432
• EINECS: -0
• Mol File: 108491-55-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: benzyl (R)-2-oxoazepan-3-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl (R)-2-oxoazepan-3-ylcarbamate(108491-55-0)
• EPA Substance Registry System: benzyl (R)-2-oxoazepan-3-ylcarbamate(108491-55-0)

Safety Data

• Hazardous Substances Data: 108491-55-0(Hazardous Substances Data)

Upstream product

• 70671-54-4 N^α-carbobenzoxy-D-lysine 

Relevant articles and documents

Rapid and Mild Lactamization Using Highly Electrophilic Triphosgene in a Microflow Reactor

Lactams are cyclic amides that are indispensable as drugs and as drug candidates. Conventional lactamization includes acid-mediated and coupling-agent-mediated approaches that suffer from narrow substrate scope, much waste, and/or high cost. Inexpensive, less-wasteful approaches mediated by highly electrophilic reagents are attractive, but there is an imminent risk of side reactions. Herein, a methods using highly electrophilic triphosgene in a microflow reactor that accomplishes rapid (0.5–10 s), mild, inexpensive, and less-wasteful lactamization are described. Methods A and B, which use N-methylmorpholine and N-methylimidazole, respectively, were developed. Various lactams and a cyclic peptide containing acid- and/or heat-labile functional groups were synthesized in good to high yields without the need for tedious purification. Undesired reactions were successfully suppressed, and the risk of handling triphosgene was minimized by the use of microflow technology.

N-SUBSTITUTED BENZENE SULFONAMIDES

Disclosed are N-substituted benzenesulfonamides for use intreating in treating or preventing cognitive disorders, such as Alzheimer′s Disease. Formula (I) In formula (I), R1, R2, R3, R4, R3’, R10