108545-38-6

Basic information

• Product Name: 5-Hexynoic acid, ethyl ester
• Synonyms: ETHYL 5-HEXYNOATE;.hex-5-ynoic acid ethyl ester;.ethyl-5-hexynoate;.Hex-5-insaeure-aethylester;.ethyl 5-hexynoate;.ethyl hex-5-ynoate;5-hexynoic acid ethyl ester
• CAS NO: 108545-38-6
• Molecular Formula: C8H12O2
• Molecular Weight: 140.182
• Mol File: 108545-38-6.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 5-Hexynoic acid, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Hexynoic acid, ethyl ester(108545-38-6)
• EPA Substance Registry System: 5-Hexynoic acid, ethyl ester(108545-38-6)

Safety Data

• Hazardous Substances Data: 108545-38-6(Hazardous Substances Data)

Upstream product

• 74-96-4 ethyl bromide 
• 53293-00-8 hex-5-ynoic acid 
• 2396-80-7 methyl 5-hexenoate 
• 77758-51-1 methyl hex-5-ynoate 
• 64-17-5 ethanol 
• 1289154-34-2 ethyl 2,2-diethoxycarbonylhex-5-ynoate 
• 108545-33-1 6-(2-Nitro-phenylselanyl)-hexanoic acid methyl ester 

Downstream Products

• 53293-00-8 hex-5-ynoic acid 
• 1289154-47-7 N-allyl-6-(4-methoxyphenyl)-4-hexynamide 
• 1289154-40-0 ethyl 5-(4-methoxyphenyl)-5-hexynoate 
• 1581276-52-9 C₂₀H₁₉BO₅ 
• 1581276-14-3 ethyl 6-(2-hydroxyphenyl)hex-5-ynoate 
• 1581276-13-2 ethyl 6-(2-(methoxymethoxy)phenyl)hex-5-ynoate 
• 77758-51-1 methyl hex-5-ynoate 
• 344904-65-0 (Z)-6-[4-(2,3-Dihydro-indol-1-ylcarbamoyl)-phenyl]-hex-5-enoic acid 
• 344904-64-9 4-((Z)-5-Ethoxycarbonyl-pent-1-enyl)-benzoic acid 2-methoxy-ethoxymethyl ester 
• 344904-63-8 4-((Z)-5-Ethoxycarbonyl-pent-1-enyl)-benzoic acid 
• 398507-44-3 tert-butyl (3-{6-[3,5-diformyl-4-(methoxymethoxy)phenyl]hex-5-ynoylamino}propyl)carbamate 

Relevant articles and documents

A bioorthogonal ligation of cyclopropenones mediated by triarylphosphines

Bioorthogonal chemistries have been widely used to probe biopolymers in living systems. To date, though, only a handful of broadly useful transformations have been identified because of the stringent requirements placed on the reactants. Here we report a novel bioorthogonal ligation between cyclopropenones and functionalized phosphines. These components are stable in physiological buffers and react rapidly with one another to form covalent adducts. The cyclopropenone ligation is also distinct from other bioorthogonal chemistries in that it makes use of readily accessible, commercially available reagents and proceeds via a nucleophilic reaction pathway. On the basis of these features, the cyclopropenone ligation is poised to join the ranks of chemistries with utility in living systems.

INDAZOLES AS LRRK2 INHIBITORS

The present invention is directed to indazole compounds which are inhibitors of LRRK2 and are useful in the treatment of CNS disorders.

Catalyst-Free Synthesis of Borylated Lactones from Esters via Electrophilic Oxyboration

A catalyst-free oxyboration reaction of alkynes is developed. The resulting borylated isocoumarins and 2-pyrones are isolated as boronic acids, pinacolboronate esters, or potassium organotrifluoroborate salts, providing a variety of bench-stable organobor