108608-00-0Relevant articles and documents
Anthranilic acid analogs
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, (2008/06/13)
Compounds of the formula: STR1 wherein: R1, R2, R3, R4, R5, R6, R7 and R8 are, independently, hydrogen, COOR15, halogen, nitro, cyano, C1-10 alkoxy, C1-10 haloalkoxy, sulfonic acid, C1-10 alkylsulfonyl, C6-12 arylsulfonyl, C6-12 aralkylsulfonyl, C1-10 alk
Synthesis and Biological Evaluation of 2-Styrylquinazolin-4(3H)-ones, a New Class of Antimitotic Anticancer Agents Which Inhibit Tubulin Polymerization
Jiang, J. B.,Hesson, D. P.,Dusak, B. A.,Dexter, D. L.,Kang, G. J.,Hamel, E.
, p. 1721 - 1728 (2007/10/02)
A novel series of 2-styrylquinazolin-4(3H)-ones which inhibited tubulin polymerization and the growth of L1210 murine leukemia cells was discovered.Extensive structure-activity relationship studies suggest that the entire quinazolinone structure was requi