108635-83-2

Basic information

• Product Name: 1-[1-(4-Fluorobenzyl)-1H-BenziMidazole-2yl]-N-Methyl-4-piperidineaMine
• Synonyms: 1-[1-(4-Fluorobenzyl)-1H-BenziMidazole-2yl]-N-Methyl-4-piperidineaMine;1-{1-[(4-Fluorophenyl)methyl]-1H-benzimidazol-2-yl}-N-methyl-4-piperidinamine 1-[1-(4-Fluorobenzyl)-1H-BenziMidazole-2yl]-N-Methyl-4-piperidineaMine
• CAS NO: 108635-83-2
• Molecular Formula: C₂₀H₂₃FN₄
• Molecular Weight: 339.4297632
• EINECS: 1308068-626-2
• Mol File: 108635-83-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 519.6±60.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• PKA: 10.05±0.20(Predicted)
• CAS DataBase Reference: 1-[1-(4-Fluorobenzyl)-1H-BenziMidazole-2yl]-N-Methyl-4-piperidineaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[1-(4-Fluorobenzyl)-1H-BenziMidazole-2yl]-N-Methyl-4-piperidineaMine(108635-83-2)
• EPA Substance Registry System: 1-[1-(4-Fluorobenzyl)-1H-BenziMidazole-2yl]-N-Methyl-4-piperidineaMine(108635-83-2)

Safety Data

• Hazardous Substances Data: 108635-83-2(Hazardous Substances Data)

Usage

Uses

Mizilastine intermediate

Upstream product

• 45584-07-4 (4-piperidyl)methylamine 
• 84946-20-3 2-chloro-1-(4-fluorobenzyl)-1H-benzimidazole 
• 680233-11-8 1-[1-(4-fluorobenzyl)-1H-benzimidazol-2-yl]-4-piperidone 

Relevant articles and documents

Brain-penetrating 2-aminobenzimidazole H1-antihistamines for the treatment of insomnia

The benzimidazole core of the selective non-brain-penetrating H1-antihistamine mizolastine was used to identify a series of brain-penetrating H1-antihistamines for the potential treatment of insomnia. Using cassette PK studies, brain

BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Benzimidazole derivatives corresponding to the formula (1) STR1 in which X is CH or N,R 1 is either a hydrogen atom, or a benzyl radical which can bear 1 to 3 substituents chosen from halogen atoms and trifluoromethyl, (C 1-4)alkyl, (C 1-4)alkoxy, c