1086601-87-7

Basic information

• Product Name: 1-(2-bromo-4-chlorophenyl)ethanol
• Synonyms: 1-(2-bromo-4-chlorophenyl)ethanol
• CAS NO: 1086601-87-7
• Molecular Weight: 235.508
• Mol File: 1086601-87-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 1-(2-bromo-4-chlorophenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromo-4-chlorophenyl)ethanol(1086601-87-7)
• EPA Substance Registry System: 1-(2-bromo-4-chlorophenyl)ethanol(1086601-87-7)

Safety Data

• Hazardous Substances Data: 1086601-87-7(Hazardous Substances Data)

Upstream product

• 74-83-9 methyl bromide 
• 84459-33-6 2-bromo-4-chlorobenzaldehyde 
• 75-16-1 methylmagnesium bromide 
• 825-40-1 2-bromo-p-chloroacetophenone 

Downstream Products

• 1415130-74-3 ethyl 3-(5-(5-chloro-2-(1-((4'-fluoro-[1,1'-biphenyl]-4-yl)amino)ethyl)phenyl)picolinamido)propanoate 
• 1414931-70-6 Ethyl 5'-chloro-2'-(1-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxylate 
• 825-40-1 2-bromo-p-chloroacetophenone 
• 1415128-92-5 3-(5-(5-chloro-2-(1-((4'-fluoro-[1,1'-biphenyl]-4-yl)amino)ethyl)phenyl)picolinamido)propanoic acid 
• 1414931-69-3 N-(1-(2-bromo-4-chlorophenyl)ethyl)-4'-chloro-[1,1'-biphenyl]-4-amine 
• 1414931-82-0 5'-chloro-2'-(1-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxylic acid 
• 1414931-39-7 3-(5'-chloro-2'-(1-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)ethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoic acid 
• 1414931-71-7 ethyl 3-(5'-chloro-2'-(1-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)ethyl)-[1,1'-biphenyl]-4-ylcarboxamido)propanoate 
• 1086599-76-9 1-(2-bromo-4-chlorophenyl)ethanamine 

Relevant articles and documents

α-Oxocarboxylic Acids as Three-Carbon Insertion Units for Palladium-Catalyzed Decarboxylative Cascade Synthesis of Diverse Fused Heteropolycycles

A novel palladium-catalyzed decarboxylative cascade cyclization for the assembly of diverse fused heteropolycycles by employing α-oxocarboxylic acids as three-carbon insertion units is reported. This protocol enables the synthesis of isoquinolinedione- and indolo[2,1-a]isoquinolinone-fused benzocycloheptanones in moderate to good yields by the use of different aryl iodides, including alkene-tethered 2-iodobenzamides and 2-(2-iodophenyl)-1H-indoles. Notably, the approach achieves simultaneous construction of both six- and seven-membered rings via sequential intramolecular carbopalladation, C-H activation, and decarboxylation.

The intramolecular reaction of acetophenoneN-tosylhydrazone and vinyl: Br?nsted acid-promoted cationic cyclization toward polysubstituted indenes

In the presence of TsNHNH2, a Br?nsted acid-promoted intramolecular cyclization ofo-(1-arylvinyl) acetophenone derivatives was developed, leading to polysubstituted indenes with complexity and diversity in moderate to excellent yields. In sharp contrast with either the radical or carbene involved cyclization of aldehydicN-tosylhydrazone with vinyl, a cationic cyclization pathway was involved, whereN-tosylhydrazone served as an electrophile and alkylation reagent during this transformation.

PdII-Catalyzed Oxidative Tandem aza-Wacker/Heck Cyclization for the Construction of Fused 5,6-Bicyclic N,O-Heterocycles

A PdII-catalyzed oxidative tandem cyclization was developed for the construction of fused 5,6-bicyclic N, O-heterocycles. This reaction was enabled by the combined use of a 3-methylpyridine ligand and pentafluorobenzoic acid additive. A range of heterocyclic products with different substituents could be prepared in moderate to good yields via this methodology. Several transformations, including a scaled-up preparation of product 2 a, were also carried out showing the good applicability of our methodology.