108714-89-2

Basic information

• Product Name: Carbamic acid, (2-methylphenyl)-, phenylmethyl ester (9CI)
• Synonyms: Carbamic acid, (2-methylphenyl)-, phenylmethyl ester (9CI);o-Tolyl-carbamic acid benzyl ester;benzyl 2-methylphenylcarbamate
• CAS NO: 108714-89-2
• Molecular Formula: C₁₅H₁₅NO₂
• Molecular Weight: 241.2851
• Product Categories: N-CBZ
• Mol File: 108714-89-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, (2-methylphenyl)-, phenylmethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (2-methylphenyl)-, phenylmethyl ester (9CI)(108714-89-2)
• EPA Substance Registry System: Carbamic acid, (2-methylphenyl)-, phenylmethyl ester (9CI)(108714-89-2)

Safety Data

• Hazardous Substances Data: 108714-89-2(Hazardous Substances Data)

Upstream product

• 124-38-9 carbon dioxide 
• 100-51-6 benzyl alcohol 
• 615-37-2 ortho-methylphenyl iodide 
• 621-84-1 O-benzyl carbamate 
• 3422-03-5 benzyloxycarbonyl azide 
• 16419-60-6 2-Methylphenylboronic acid 
• 62673-31-8 benzyl(bromo)zinc 
• 614-68-6 2-tolyl isocyanate 
• 933-88-0 ortho-toluoyl chloride 
• 2028-34-4 o-toluene-diazonium chloride 

Downstream Products

• 620-05-3 iodomethylbenzene 
• 1067891-50-2 benzyl ((2-methyloxiran-2-yl)methyl)(o-tolyl)carbamate 
• 1118917-05-7 methyl o-tolyl carbamic acid 1-benzyl ester 
• 614-68-6 2-tolyl isocyanate 
• 100-51-6 benzyl alcohol 

Relevant articles and documents

Interrupted aza-Wittig reactions using iminophosphoranes to synthesize 11C-carbonyls

A direct CO2-fixation methodology couples structurally diverse iminophosphoranes with various nucleophiles to synthesize ureas, carbamates, thiocarbamates, and amides, and is amenable for 11C radiolabeling. This methodology is practical, as demonstrated by the synthesis of >35 products and isolation of the molecular imaging radiopharmaceuticals [11C]URB694 and [11C]glibenclamide. This journal is

Copper-Catalyzed Domino [1,3]/[1,2] Rearrangement for the Efficient Synthesis of Multisubstituted ortho-Anisidines

Multisubstituted ortho-anisidines were efficiently synthesized via cationic N-heterocyclic carbene-Cu-catalyzed domino rearrangement of N-methoxyanilines that possess an electron-donating functional group, such as an alkyl or an aryl group, at the ortho position. The reaction proceeded first through a [1,3]-rearrangement of the methoxy group to the ortho position bound to the electron-donating substituent, followed by a semipinacol type [1,2]-rearrangement of the electron-donating group from the ortho to the meta position. Mechanistic studies suggest that both rearrangement reactions are promoted by a cationic Cu catalyst.

A synthetic approach to N -aryl carbamates via copper-catalyzed Chan-Lam coupling at room temperature

A mild and efficient synthesis of N-arylcarbamates was achieved by reacting azidoformates with boronic acids in the presence of 10 mol % of copper chloride catalyst. The reaction proceeds readily in an open flask at room temperature without additional base, ligand, or additive. Rapid access to urea analogues via a two-step one-pot procedure is enabled by reacting N-arylcarbamates with aluminum-amine complexes. In addition, among several boronic acid derivatives prepared, dimethylphenyl boronate was found to react rapidly in its reaction with benzyl azidoformate, invoking in situ generation of this species in the catalytic cycle.