108781-66-4

Basic information

• Product Name: 2-Naphthalenemethanol, 6-methoxy-a-methyl-, acetate, (R)-
• CAS NO: 108781-66-4
• Molecular Formula: C15H16O3
• Molecular Weight: 244.29
• Mol File: 108781-66-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Naphthalenemethanol, 6-methoxy-a-methyl-, acetate, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Naphthalenemethanol, 6-methoxy-a-methyl-, acetate, (R)-(108781-66-4)
• EPA Substance Registry System: 2-Naphthalenemethanol, 6-methoxy-a-methyl-, acetate, (R)-(108781-66-4)

Safety Data

• Hazardous Substances Data: 108781-66-4(Hazardous Substances Data)

Upstream product

• 876-27-7 4-chlorophenyl acetate 
• 108781-65-3 1-(6-methoxy-2-naphthyl)ethanol 

Downstream Products

• 3900-45-6 6-methoxy-2-acetylnaphthalene 
• 68520-00-3 1-(6-(dimethylamino)naphthalen-2-yl)ethan-1-one 
• 108781-68-6 2-Methoxy-6-((Z)-1-methyl-3-phenyl-allyl)-naphthalene 
• 23981-80-8 naproxen 
• 108781-67-5 2-Methoxy-6-(1-methyl-3-phenyl-prop-2-ynyl)-naphthalene 

Relevant articles and documents

Racemization of secondary alcohols catalyzed by ruthenium: Application to chemoenzymatic dynamic resolution

In this paper, we have shown that the [RuCl2(p-cymene)] 2 complex associated with simple hemisalen ligands is able to racemize (S)-1-phenylethanol. The influence on the racemization process of the ligand's structure as well as the nature of a co-catalyst have been evaluated and optimized. This [RuCl2(p-cymene)]2/Ligand/TEMPO racemization system was then associated with the Candida Antarctica B lipase in order to carry out dynamic kinetic resolution experiments on rac-phenylethanol. This led us to identify the best conditions for effective DKR, which was then applied to various secondary benzylic and aliphatic alcohols. It was thus possible to obtain (R)-1-cyclohexylethyl acetate from rac-1-cyclohexylethanol in quantitative conversion and with high enantioselectivity (98%).