108783-01-3

Basic information

• Product Name: 2-[2-(4,4'-dimethoxytrityloxy)ethylsulfonyl]ethanol
• Synonyms: 2-[2-(4,4'-dimethoxytrityloxy)ethylsulfonyl]ethanol
• CAS NO: 108783-01-3
• Molecular Weight: 456.56
• Mol File: 108783-01-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-[2-(4,4'-dimethoxytrityloxy)ethylsulfonyl]ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(4,4'-dimethoxytrityloxy)ethylsulfonyl]ethanol(108783-01-3)
• EPA Substance Registry System: 2-[2-(4,4'-dimethoxytrityloxy)ethylsulfonyl]ethanol(108783-01-3)

Safety Data

• Hazardous Substances Data: 108783-01-3(Hazardous Substances Data)

Upstream product

• 2580-77-0 sulfonyldiethanol 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 1443045-20-2 C₂₅H₂₉O₈PS*C₆H₁₅N 
• 108783-02-4 2-[2-(4,4'-dimethoxytrityloxy)ethylsulfonyl]ethyl-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite 

Relevant articles and documents

Recognition and inhibition of HIV integrase by novel dinucleotides

HIV integrase is involved in the integration of viral DNA into chromosomal DNA, a biological process that occurs by a sequence involving HIV DNA splicing and subsequent integration steps. In the quest for small nucleotide systems with nuclease stability of the internucleotide phosphate bond and critical structural features for recognition and inhibition of HIV-1 integrase, we have discovered novel, nuclease-resistant dinucleotides with defined base sequences that are inhibitors of this key viral enzyme. Synthetic methodologies utilized for the syntheses of the novel dinucleotides include an excellent new phosphorylating agent.

A CHEMICAL 5'-PHOSPHORYLATION OF OLIGODEOXYRIBONUCLEOTIDES THAT CAN BE MONITORED BY TRITYL CATION RELEASE

A new phosphoramidite-derived reagent, (2-cyanoethoxy)-2-(2'-O-4,4'-dimethoxytrityloxyethylsulfonyl)ethoxy-N,N-diisopropylaminophosphine, for the 5'-phosphorylation of oligodeoxyribonucleotides has been developed.Phosphorylation efficiency can be determined by the release of 4,4'-dimethoxytrityl cation in acid.