108791-61-3Relevant articles and documents
A Topliss tree analysis of the HIV-protease inhibitory activity of 6- phenyl-4-hydroxy-pyran-2-ones
Steinbaugh,Hamilton,Prasad,Para,Tummino,Ferguson,Lunney,Blankley
, p. 1099 - 1104 (2007/10/03)
In a study of 4-hydroxy-pyran-2-ones as possible inhibitors of HIV protease, a series of compounds were synthesized following the Topliss operational scheme for substitution on a phenyl group at the 6 position of the pyrone. In addition, a number of compounds with polar substituents were made.