108806-50-4Relevant articles and documents
Phenylene derivatives and anti-allergic use thereof
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, (2008/06/13)
Novel phenylene derivatives shown by the general formula STR1 wherein A represents a hydrogen atom, a phenyl group or a phenoxy group, n represents an integer of 3 to 10, R1 represents a hydrogen atom or a lower alkoxy group, X1 represents --CH2 CH2 --, --CH=CH--, --CONH--, B represents STR2 (wherein R2 represents a hydrogen atom, a halogen atom, a nitro group, etc.), STR3 (wherein R3 represents a hydrogen atom, a hydroxyl group or a lower alkoxy group), X2 represents --CH=CH--, --CH2 CH2 --, etc. and D represents a carboxy group, a lower alkoxycarbonyl group or STR4 which are useful as drugs, particularly SRS-A (slow reacting substance of anaphylaxis) antagonist, i.e. they are useful as prophylaxis and treatment for various allergic diseases (e.g. bronchial asthma, allergic rhinitis, urticaria) or, ischemic heart diseases, inflammation, etc. induced by SRS-A.