108981-94-8

Basic information

• Product Name: 2-Phenylnaphthalene-1-carboxylic acid
• Synonyms: 2-Phenylnaphthalene-1-carboxylic acid;2-phenyl-1-naphthoic acid
• CAS NO: 108981-94-8
• Molecular Formula: C₁₇H₁₂O₂
• Molecular Weight: 248.27598
• Mol File: 108981-94-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Phenylnaphthalene-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenylnaphthalene-1-carboxylic acid(108981-94-8)
• EPA Substance Registry System: 2-Phenylnaphthalene-1-carboxylic acid(108981-94-8)

Safety Data

• Hazardous Substances Data: 108981-94-8(Hazardous Substances Data)

Upstream product

• 479-79-8 11H-Benzo[a]fluoren-11-one 
• 60-29-7 diethyl ether 
• 323-09-1 2-fluoronaphthalene 
• 591-51-5 phenyllithium 
• 321-38-0 1-Fluoronaphthalene 
• 2051-10-7 5,6-chrysenedione 
• 7647-01-0 hydrogenchloride 
• 412033-93-3 2-(2-carbamoyl-phenyl)-[1]naphthoic acid 
• 129633-49-4 cis-2,6-bis(tert-butyl)-4-methoxyphenyl 2-phenyl-1,2-dihydro-1-naphthalenecarboxylate 
• 86-55-5 1-naphthalenecarboxylic acid 
• 947-62-6 2-methoxy-1-naphthoic acid 
• 100-58-3 phenylmagnesium bromide 
• 591-50-4 iodobenzene 
• 108-90-7 chlorobenzene 

Downstream Products

• 109251-89-0 methyl 2-phenylnaphthalene-1-ylcarboxylate 

Relevant articles and documents

Palladium-Catalyzed Annulation of Arylbenzamides with Diaryliodonium Salts

By using diaryliodonium salts, a cylization has been accomplished in the synthesis of N-aryl phenanthridinone derivatives via a cascade of ortho-arylation and Csp2-N bond formation in the presence of palladium catalyst. The reaction exhibits a broad compatibility of readily available N-arylnaphthamides. (Figure presented.).

Ruthenium-Catalyzed C-H Arylation of Diverse Aryl Carboxylic Acids with Aryl and Heteroaryl Halides

Ruthenium ligated to tricyclohexylphosphine or di-tert-butylbipyridine catalyzes the arylation of carboxylic acids with diverse aryl halides (iodide, bromide, and triflate; aryl and heteroaryl). In addition, arylations with 2-iodophenol formed benzochromenones, carboxylate was shown to be a stronger donor than an amide, and the arylation of a pyridine carboxylate was demonstrated. Stoichiometric studies demonstrated that the added ligand is required for reaction with the electrophile but not the C-H bond.

Ortho-lithium/magnesium carboxylate-driven aromatic nucleophilic substitution reactions on unprotected naphthoic acids

Substitution of an ortho-fluoro or methoxy group in 1- and 2-naphthoic acids furnishing substituted naphthoic acids occurs in good to excellent yields upon reaction with alkyl/vinyl/aryl organolithium and Grignard reagents, in the absence of a metal catalyst without the need to protect the carboxyl (CO 2H) group. This novel nucleophilic aromatic substitution is presumed to proceed via a precoordination of the organometallic with the substrate, followed by an addition/elimination.