109019-72-9Relevant articles and documents
Polyaza heterocycles. Part 3. Halogenation of 1-substituted quinoxalinocinnolines: mechanistic implications
Harvey, Ian W.,Smith, David M.,White, Charles R.
, p. 1699 - 1704 (2007/10/03)
Since it has been proposed that halogenation of quinoxalinocinnolines at C-10, using hydrogen chloride or bromide in chloroform, occurs through initial protonation of the substrate at N-12, attempts have been made to inhibit this protonation by the introduction of an additional substituent at C-1.Where this substituent is chloro, bromo or methyl, chlorination still occurs preferentially at C-10, although the yield and the reaction rate decrease along the series, lending weight to the mechanistic proposal.
