109133-94-0Relevant articles and documents
Synthesis of regiospecifically substituted quinolines from anilines
Chelucci, Giorgio,Manca, Ilaria,Pinna, Gerard A.
, p. 767 - 770 (2005)
A protocol for the synthesis of quinolines substituted on both pyridine and benzo-fused rings is reported. The method is based on the formylation of a substituted N-(tert-butoxycarbonyl)aniline followed by direct cyclisation and aromatisation of the inter
The synthesis and structure-activity relationships of 3-amino-4- benzylquinolin-2-ones: Discovery of novel KCNQ2 channel openers
Hewawasam, Piyasena,Chen, Nathan,Ding, Min,Natale, Joanne T.,Boissard, Christopher G.,Yeola, Sarita,Gribkoff, Valentin K.,Starrett, John,Dworetzky, Steven I.
, p. 1615 - 1618 (2007/10/03)
3-Amino-4-benzylquinolin-2-ones have been identified as a novel class of KCNQ2 channel openers. Synthesis and SAR is described along with their electrophysiological evaluation as activators of the cloned mKCNQ2 channel expressed in Xenopus laevis oocytes.
Imidazoquinoline antithrombrogenic cardiotonic agents
-
, (2008/06/13)
Novel series of 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-ones of the Formula STR1 wherein R1 is halogen, lower alkyl, lower alkoxy, trifluoromethyl; R2 is hydrogen, halogen, lower alkyl, lower alkoxy; R3 is hydrogen, haloge
