109183-56-4 Usage
Description
21-Acetyloxy DeschloroMoMetasone Furoate 9,11-Epoxide is a white solid chemical compound that serves as a crucial reactant in the synthesis of anti-inflammatory corticosteroids. Its unique structure allows it to be a key component in the preparation of furoyl and thenoyl esters of corticosteroids, which are widely used for their potent anti-inflammatory properties.
Uses
Used in Pharmaceutical Industry:
21-Acetyloxy DeschloroMoMetasone Furoate 9,11-Epoxide is used as a reactant for the preparation of anti-inflammatory furoyl and thenoyl esters of corticosteroids. Its role in the synthesis process is essential for creating effective medications that help manage inflammation and other immune responses in various medical conditions.
As a reactant in the pharmaceutical industry, 21-Acetyloxy DeschloroMoMetasone Furoate 9,11-Epoxide contributes to the development of corticosteroid-based drugs that are used for treating a range of inflammatory and autoimmune disorders. These disorders may include, but are not limited to, asthma, allergies, rheumatoid arthritis, and various skin conditions such as eczema and psoriasis. The anti-inflammatory properties of the resulting corticosteroids are attributed to their ability to modulate the immune system and reduce the production of inflammatory mediators.
Check Digit Verification of cas no
The CAS Registry Mumber 109183-56-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,1,8 and 3 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 109183-56:
(8*1)+(7*0)+(6*9)+(5*1)+(4*8)+(3*3)+(2*5)+(1*6)=124
124 % 10 = 4
So 109183-56-4 is a valid CAS Registry Number.
109183-56-4Relevant articles and documents
17-Heteroaroyl Esters of Corticosteroids. 2. 11β-Hydroxy Series
Shapiro, Elliot L.,Gentles, Margaret J.,Tiberi, Robert L.,Popper, Thomas L.,Berkenkopf, Joseph,et al.
, p. 1581 - 1588 (2007/10/02)
The preparation and topical antiinflammatory potencies of a series of 17-furoyl and -thenoyl esters of 9α-fluoro-11β-hydroxy-16-methyl and 9α-chloro-11β-hydroxy-16-methyl corticosteroids are described.The 17α-esters were introduced to the 9α-fluoro 11-ketones or the appropriate Δ9(11) compounds by direct acylation with the appropriate heteroaryl carbonyl chloride in the presence of 4-(dimethylamino)pyridine.Functionalization of the C ring was completed by standard methods.The most extensively studied heterocyclic acyl group was 2-furoyl, but 3-furoyl and 2- and 3-thienoyl derivatives were also investigated.Antiinflammatory potencies were measured in mice by a 5-day modification of the Tonelli croton oil ear assay.The most potent topical antiinflammatory agents were 1e, dexamethasone 17-(2'-furoate)-21-propionate, and 2c, the 21-chloro 17-(2'-furoate) in the 9α-chloro series, both being 6 times as potent as betamethasone 17-valerate.Several other 9α-chloro-11β-hydroxy-17-heteroaryl carboxylates (2a, 2b, 2d and 2g) were at least 4 times as potent as betamethasone 17-valerate.Evaluation of 2c in the clinic confirmed that the compound is a potent topical antiinflammatory agent in humans.
