1092331-89-9Relevant articles and documents
Palladium-catalyzed benzo[d]isoxazole synthesis by C-H activation/[4 + 1] annulation
Duan, Pingping,Yang, Yunfang,Ben, Rong,Yan, Yiyong,Dai, Lu,Hong, Mei,Wu, Yun-Dong,Wang, Dongqi,Zhang, Xinhao,Zhao, Jing
, p. 1574 - 1578 (2014)
We report a palladium-catalyzed intermolecular [4 + 1] annulation pathway for N-phenoxyacetamides with aldehydes to form 1,2-benzisoxazoles. By activating the C-H bonds ortho to phenol-derived O-N bonds, the method enables the simultaneous construction of C-C and CN bonds in 1,2-benzisoxazoles with the O-N bonds intact. The method has been successfully applied to the synthesis of active pharmaceutical intermediates, such as risperidone.