1092399-76-2Relevant articles and documents
Synthesis and Performance of a Biomimetic Indicator for Alkylating Agents
Provencher, Philip A.,Love, Jennifer A.
, p. 9603 - 9609 (2015)
4-(4-Nitrobenzyl)pyridine (NBP) is a colorimetric indicator compound for many types of carcinogenic alkylating agents. Because of the similar reactivity of NBP and guanine in DNA, NBP serves as a DNA model. NBP assays are used in the toxicological screeni
Harnessing the reactivity of Ortho-formyl-arylketones: Base-promoted regiospecific synthesis of functionalized isoquinolines
Mishra, Pawan K.,Verma, Shalini,Kumar, Manoj,Kumar, Ankit,Verma, Akhilesh K.
, p. 8278 - 8281 (2019/07/16)
An efficient and base-mediated one-pot regiospecific synthesis of structurally diversified isoquinolines and benzo[h] isoquinolines from easily accessible ortho-formyl-arylketones and aryl/(het)arylmethanamines has been described. Challenging 3-alkynyl/alkenyl isoquinolines and bis-isoquinolines were easily attained through this developed chemistry, which can be further used for various organic transformations. Operational simplicity, high atom-economy, broad substrate scope, functional group tolerance and applicability towards large scale synthesis are the advantageous features of this developed methodology.