1092493-80-5Relevant articles and documents
Novel practical deprotection of N-Boc compounds using fluorinated alcohols
Choy, Jason,Jaime-Figueroa, Saul,Jiang, Laurence,Wagner, Paul
, p. 3840 - 3853 (2008)
The thermolytic deprotection of N-Boc compounds was accomplished using TFE (2,2,2-trifluoroethanol) or HFIP (hexafluoroisopropanol) as solvents. Even though the cleavage of the t-butylcarbamate (Boc) group can be achieved at solvent reflux temperature, the deprotection process was significantly accelerated under microwave-assisted conditions. The practicality of this methodology was demonstrated on alkyl, aryl, and heteroaromatic N-Boc-amines. Copyright Taylor & Francis Group, LLC.
Deprotection of N-BOC compounds
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Page/Page column 5-6, (2009/07/10)
Organic compounds having nitrogen atoms protected with t-butoxycarbonyl are effectively deprotected by heating in a fluorinated alcohol solution.