1092540-46-9 Usage
Description
(S)-2-((R)-2-amino-2-oxo-1-phenylethylamino)-3,3-d9-dimethylbutanamide is a complex organic compound with a unique molecular structure. It is characterized by its deuterated nature, which involves the presence of deuterium (D) atoms, an isotope of hydrogen, in its molecular structure. (S)-2-((R)-2-amino-2-oxo-1-phenylethylamino)-3,3-d9-dimethylbutanamide is of particular interest due to its potential applications in various fields, including pharmaceuticals and chemical research.
Uses
Used in Pharmaceutical Industry:
(S)-2-((R)-2-amino-2-oxo-1-phenylethylamino)-3,3-d9-dimethylbutanamide is used as a key intermediate in the synthesis of deuterated analogs of pharmaceutical compounds. Its deuterated nature may provide enhanced stability and improved pharmacokinetic properties compared to their non-deuterated counterparts.
Used in the Synthesis of Deuterated Analogs:
(S)-2-((R)-2-amino-2-oxo-1-phenylethylamino)-3,3-d9-dimethylbutanamide is used as a starting material for the synthesis of deuterated analogs of various drugs, including the hepatitis C virus protease inhibitor boceprevir. The incorporation of deuterium into the molecular structure can lead to improved metabolic stability and potentially better therapeutic outcomes for patients.
Used in Chemical Research:
(S)-2-((R)-2-amino-2-oxo-1-phenylethylamino)-3,3-d9-dimethylbutanamide can also be utilized in chemical research to study the effects of deuterium substitution on the reactivity, stability, and overall behavior of molecules. This knowledge can be applied to the development of new drugs and materials with enhanced properties.
Check Digit Verification of cas no
The CAS Registry Mumber 1092540-46-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,2,5,4 and 0 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1092540-46:
(9*1)+(8*0)+(7*9)+(6*2)+(5*5)+(4*4)+(3*0)+(2*4)+(1*6)=139
139 % 10 = 9
So 1092540-46-9 is a valid CAS Registry Number.
1092540-46-9Relevant articles and documents
Design and synthesis of deuterated boceprevir analogs with enhanced pharmacokinetic properties
Morgan, Adam J.,Nguyen, Sophia,Uttamsingh, Vinita,Bridson, Gary,Harbeson, Scott,Tung, Roger,Masse, Craig E.
experimental part, p. 613 - 624 (2011/12/03)
As part of an ongoing effort to apply the Deuterated Chemical Entity Platform (DCE Platforma) to clinically validated drugs, the synthesis of deuterated analogs of the hepatitis C virus protease inhibitor boceprevir was carried out. The devised synthetic routes allowed for site-selective deuterium incorporation with high levels of isotopic purity. Application of the DCE Platforma to boceprevir enabled the identification of several deuterated analogs that display marked levels of in vitro metabolic stabilization. Most notably, analog 1g exhibits a near doubling of in vitro half-life in human liver microsomal assays. The details of the convergent synthetic route to the boceprevir isotopologs and the results of the metabolic stability assays are described herein.
