1092577-93-9

Basic information

• Product Name: C₁₇H₂₆N₂O₂S
• CAS NO: 1092577-93-9
• Molecular Weight: 322.472
• Mol File: 1092577-93-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₇H₂₆N₂O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₂₆N₂O₂S(1092577-93-9)
• EPA Substance Registry System: C₁₇H₂₆N₂O₂S(1092577-93-9)

Safety Data

• Hazardous Substances Data: 1092577-93-9(Hazardous Substances Data)

Upstream product

• 137496-70-9 (S)-tert-butyl 2-((3,5-dimethylphenyl)carbamoyl)pyrrolidine-1-carboxylate 
• 108-69-0 3,5-dimethylaminoaniline 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 31562-43-3 tert-butylsulfinyl chloride 
• 220037-58-1 (S)-Pyrrolidine-2-carboxylic acid (3,5-dimethyl-phenyl)-amide 

Relevant articles and documents

Chiral Lewis Base-Catalyzed, Enantioselective Reduction of Unprotected β-Enamino Esters with Trichlorosilane

Catalytic asymmetric reduction of N-unsubstituted β-enamino esters represents a major challenge for asymmetric catalysis. In this paper, the first organocatalytic system that could be used for the asymmetric hydrosilylation of N-unsubstituted β-enamino esters has been developed. Using N-tert-butylsulfinyl-L-proline-derived amides and L-pipecolinic acid-derived formamides as catalyst, a broad range of β-aryl- and β-alkyl-substituted free β-amino esters could be prepared with high yields and enantioselectivities. The practicality was illustrated by the gram-scale asymmetric synthesis of ethyl (R)-3-amino-3-phenylpropanoate and isopropyl (S)-3-amino-4-(2,3,5-trifluorophenyl)butanoate. The resulting product can be smoothly transformed to the FDA approved medicines dapoxetine and sitagliptin in a short synthetic route.