1092578-43-2Relevant articles and documents
Method for preparing tofacitinib related impurities
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, (2017/08/29)
The invention discloses a method for preparing tofacitinib related impurities. 1-benzyl-4-methyl-3-methylamino-piperidine is taken as a raw material, the tofacitinib related impurities (TFTN-I and TFTN-II) are obtained through a series of reactions, and the yield and purity are improved by modes of extracting, concentrating and purifying reaction liquid. The tofacitinib related impurities are easy to operate in process and high in purity and have very good market application values. A qualified comparison product is provided for quality control over tofacitinib.