1092844-00-2

Basic information

• Product Name: 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carbonitrile
• Synonyms: 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carbonitrile
• CAS NO: 1092844-00-2
• Molecular Weight: 348.401
• Mol File: 1092844-00-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carbonitrile(1092844-00-2)
• EPA Substance Registry System: 4-(4-fluorophenyl)-6-isopropyl-2-[(N-methyl-N-methylsulfonyl)amino]pyrimidine-5-carbonitrile(1092844-00-2)

Safety Data

• Hazardous Substances Data: 1092844-00-2(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 29509-06-6 4-methyl-3-oxopentanonitrile 
• 1184-85-6 N-methylmethane sulphonamide 
• 1416158-43-4 4-(4-fluorophenyl)-2-hydroxy-6-isopropylpyrimidine-5-carboxamide 
• 1416158-42-3 4-(4-fluorophenyl)-6-isopropyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxamide 
• 34126-90-4 4-methyl-3-oxopentanamide 
• 42558-54-3 Methyl 4-methyl-3-oxopentanoate 

Downstream Products

• 147118-37-4 N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide 

Relevant articles and documents

A formyl rosuvastatin salts calcium intermediate preparation method

The invention discloses a preparation method of a formoxyl rosuvastatin calcium intermediate. With 2-methyl-3-carbonyl valeronitrile, 4-fluorobenzaldehyde and urea as raw materials, the formoxyl rosuvastatin calcium intermediate 4-(4-fluorophenyl)-2-hydroxy-6-isopropyl-5-formoxyl-2-(N-methyl-N-methylsulfonyl) pyrimidine is synthesized by reactions such as cyclization, oxidation, N-substitution and reduction. Compared with an existing method, the method has the advantages that reaction conditions are mild, the used reagent is relatively cheap and the yield is high.

IMPROVED PROCESS FOR PREPARING STATIN PRECURSOR

The present invention relates to a process for preparing a statin precursor, which process comprises a first reaction step, wherein a hydroxy-pyrimidine-carbonitrile is reacted with an organic sulfonyl halide to form the sulfonate-pyrimidine-carbonitrile; a second reaction step, wherein the sulfonate-pyrimidine-carbonitrile is reacted with N-methylmethane sulfonamide to form a pyrimidinyl-sulfonamide; and optionally a third reaction step, wherein the pyrimidinyl-sulfonamide is reacted with a reducing agent. All steps are conducted in toluene as the main solvent.